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Zyprexa *never* for depression!

Posted by Tye on March 30, 2002, at 13:35:16

In reply to zyprexa for atypical depression?, posted by KB on March 28, 2002, at 20:37:47

> Has anybody had any experience with Zyprexa for atypical depression? I'm also taking Celexa and Wellbutrin, have never had any psychotic symptoms.

Hey KB,

Theorectically, zyprexa augments SSRIs by increasing norepinephrine and dopamine in the frontal lobes. Of course, the study that supports this was performed on rat brain .... and we are not rats! Also Eli Lilly, the maker or zyprexa and prozac, had a small study showing zyprexa augmented prozac in patients with depression.

In reality, zyprexa is a poor agent for depression. In fact, most patients feel more depressed/more apathy/more sedated on zyprexa. Along with the risks of tardive dyskinesia, zyprexa should probably *never* be prescribed for depression.

Of course if you have bipolar disorder or psychosis, zyprexa can be helpful.

Get better soon!





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