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Re: Zyprexa *never* for depression! Tye

Posted by JohnX2 on March 31, 2002, at 8:22:54

In reply to Zyprexa *never* for depression!, posted by Tye on March 30, 2002, at 13:35:16

> > Has anybody had any experience with Zyprexa for atypical depression? I'm also taking Celexa and Wellbutrin, have never had any psychotic symptoms.
>
> Hey KB,
>
> Theorectically, zyprexa augments SSRIs by increasing norepinephrine and dopamine in the frontal lobes. Of course, the study that supports this was performed on rat brain .... and we are not rats! Also Eli Lilly, the maker or zyprexa and prozac, had a small study showing zyprexa augmented prozac in patients with depression.
>
> In reality, zyprexa is a poor agent for depression. In fact, most patients feel more depressed/more apathy/more sedated on zyprexa. Along with the risks of tardive dyskinesia, zyprexa should probably *never* be prescribed for depression.
>
> Of course if you have bipolar disorder or psychosis, zyprexa can be helpful.
>
> Get better soon!
>
> Tye

Given a Zyprexa, minus the noradrenergic alpha-1 antagonism (which for some may induce sedation), and the dopamine antagonism (potential for tardive dyskinesia), would you retract your statement? I.e. a clean medicine that blocks the Serotonin 5-ht2a and 5-ht2c receptors, thus relieving a lot of anxiety and side effects from the current generation of antidepressants?

John



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poster:JohnX2 thread:100817
URL: http://www.dr-bob.org/babble/20020327/msgs/101084.html