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Re: zyprexa, *seoquel mode of action SLS

Posted by Geoffrey Ruch on April 19, 2004, at 22:11:55

In reply to Re: zyprexa for atypical depression? OldSchool, posted by SLS on April 1, 2002, at 13:11:09

Hello. I am new to this group.
Just to give a brief discussion of my mental health situation, I have had severe Major Depression (possibly psychotic), Social Phobia, and Post Traumatic Stress Disorder (PTSD). I have been taking Parnate (an MAO ihibitor), Lamictal, along with 15 mg of Zyprexa, and 300 mg of Seroquel.
My question is as follows:
I have been extremely confused about how atypical antipsychotic meds act. I have read that there are many different serotonin receptors, some of which are the ones associated with the SSRIs, etc., trying to increase serotonin levels when they're low. And, of course, this is related to releiving anxiety disorders such as Social Anxiety Disorder, OCD, Generalized Anxiety Disorder, Phobias, etc. But I'm very confused about how the (atypical) antipsychotics-- let alone typical antipsychotics-- act on the brain. I've read that there are several different serotonin receptors. From what I understand, the 5-HT1a receptors are what are targeted by SSRIs, and that antagonizing such other serotonin receptors as 5-HT3 can help relieve anxiety (incl. vomiting, etc.). But what about all the other serotonin receptors? Do Zyprexa and Seroquel act on these 5-HT3 receptors (antagonistically) Does anybody here understand this, as well as the dopaminergic receptors blocked by various antipsychotic medications.
If nobody here has any understanding or about this or has an idea of how to explain it, could someone perhaps refer me to a source where I can learn about it?





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