Posted by JohnX2 on March 24, 2002, at 5:45:56
In reply to Frontal lobe syndrome » Elayne, posted by BarbaraCat on March 24, 2002, at 1:15:35
What is this frontal lobe syndrome?I saw this interesting pharmaceutical which they found by accident substantially reduces "emotional lability". So they are doing clinical trials for emotional lability in ALS patients. I was wondering if the same medication may be useful for emotional lability in psychiatry.
http://www.avanir.com/product/product.php?ID=3
http://www.mdausa.org/research/ct-alsdetro.html"The basic mechanisms underlying emotional control are unknown. Lesions in a variety of areas of the brain, including the frontal and temporal lobes, have been associated with the occurrence of pathological laughing and crying. Conceptually, it may be useful to think of pseudobulbar affect as an example of a disconnection syndrome which interrupts the normal integration of cortical and brain stem functions. This is a double-blind, controlled, randomized, national, multicenter clinical study. Patients who are eligible for the clinical trial will be in the study for one month. "
I initially was looking at it and thought it might help in the areas of medication tolerance development. I also saw possible applications in PTSD/BPD/atypical anxyiolytic/indirect CRF antagonist.
The guy who came up with this med idea was using it initially to treat addicts and also other fringe disorders like tinnitus and chronic cough.
John
> Elayne,
> Talk some more about 'frontal lobe syndrome'. Is this an actual phenomenon that's being reported or researched? I worry about long term physical changes in receptor density and would be interested in any info where this is being addressed.
>
> Barbara
poster:JohnX2
thread:99188
URL: http://www.dr-bob.org/babble/20020322/msgs/99818.html