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Re: Gabitril and benzos

Posted by Stephanie S on February 4, 2002, at 15:37:00

In reply to Re: Gabitril and benzos Stephanie S, posted by Elizabeth on February 4, 2002, at 15:24:54

> ... the GABA reuptake inhibitors (as well as other GABA-based meds) might also work better/differently on different people...
> I'm sure that's true (Gabitril was the only GABA reuptake inhibitor that we were discussing, though, wasn't it?).

Yes... it was the only reuptake inhibitor... but in a couple previous posts there was discussion of some other GABA-based drugs... So I suppose I was actually saying that the mechanism of the reuptake inhibitor as compared to the mechanism of some of the others that were discussed may work better for some and worse for others... :)

Which is why many of us get varying results...

< C/P from earlier post >

"Gabitril (tiagabine) doesn't interact with benzo receptors at all. It is a GABA reuptake inhibitor (blocking the GABA transporter to increase the amount of available extracellular GABA, just as SSRIs block the serotonin transporter). Benzos (which are benzodiazepine receptor agonists) work by increasing the effectiveness of GABA at its receptor. Benzos don't directly act at the GABA receptor or increase the amount of GABA.

Another anticonvulsant, Sabril (vigabatrin), works by blocking an enzyme called GABA transaminase which is involved in the metabolism of GABA. This is analogous to the action of MAOIs on monoamines. (Nardil is also a GABA transaminase inhibitor, BTW.)"

< end c/p >

> Much more. Your expression "the GABA's" was what had me puzzled; thanks for explaining what you meant by it.

Hopefully that will help to clarify my words... I sometimes forget that just 'cause I read through the string all at once and therefore have all of it in my head at once, I'm actually replying to the post just above mine... so you read this thread over a couple months time.... and I was playing "catch up." I must use good web etiquette... I must use good web etiquette... :-P < note to self > :-)





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