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Re: Gabitril and benzos Elizabeth

Posted by Lorraine on December 30, 2001, at 23:42:20

In reply to Re: Gabitril and benzos Cmatt, posted by Elizabeth on December 28, 2001, at 13:39:19

So, e, does this mean that if you like that anti-anxiety effects of Nardil, maybe you will like Sabril:-)?


> Another anticonvulsant, Sabril (vigabatrin), works by blocking an enzyme called GABA transaminase which is involved in the metabolism of GABA. This is analogous to the action of MAOIs on monoamines. (Nardil is also a GABA transaminase inhibitor, BTW.)
> Ambien is an example of a drug that works selectively at a particular subtype of benzodiazepine receptor; it lacks many of the effects of the benzos (such as their anticonvulsant and muscle relaxant effects).
> There are two types of GABA receptors, GABA-A and GABA-B receptors. Baclofen, a medication used for spasticity, is a selective GABA-B agonist and has little effect on anxiety.
> -elizabeth




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