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Re: Gabitril and benzos Elizabeth

Posted by Stephanie S on February 3, 2002, at 12:31:20

In reply to Re: Gabitril and benzos MB, posted by Elizabeth on December 29, 2001, at 6:22:59

> There may be some important differences. For whatever reasons, Gabitril and Sabril aren't used much for anxiety (yet, anyway). I think they may be less effective than benzos.

I've had real decent anxiety relief with Gabatril... I just started it about 5 months ago... I take it in conjunction with my Zoloft... But I don't really have "panic-attack" type anxiety... mine is more jaw-clenching, finger biting, leg jiggling anxiety... :-P

> > So, since the vinyl-GABA and the Gabitril both increase GABA in the brain, does this mean that these drugs affect both types of GABA receptors? I felt no anxiety relief from the Gabitril.
> Yes, just like SSRIs have effects on all types of serotonin receptors (because they just increase the amount of serotonin, which is a nonselective serotonin receptor agonist), Sabril and Gabitril will affect both types of GABA receptors. As you've discovered, though, the road to anxiety relief may be more complicated than just agonizing GABA-A receptors.

And maybe just like we all get relief from a variety of SSRI's, the same may be true of the GABA's...





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