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Re: GABITRIL (tiagabine) new anti-anxiety drug????? leonard60

Posted by Mitch on December 31, 2001, at 10:33:01

In reply to Re: GABITRIL (tiagabine) new anti-anxiety drug?????, posted by leonard60 on December 30, 2001, at 21:43:39

> is GABITRIL any thing like gabapentin

In short no. Gabitril helps prevent GABA from being scavenged (blocks reuptake). Levels of GABA then build up and since it is an inhibitory neurotransmitter, this can help "stabilize" neuronal firing and help control seizures.

Gabapentin's molecule "looks like" the inhibitory neurotransmitter GABA, but its mechanism doesn't appear to be "GABA-ergic". Evidently, there are specific sites in the hippocampus where it acts as a selective calcium-ion channel blocker which also "stabilizes" neuronal firing but in a more selective region of the brain.


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poster:Mitch thread:86944
URL: http://www.dr-bob.org/babble/20011222/msgs/88344.html