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Re: GABITRIL (tiagabine) new anti-anxiety drug????? MB

Posted by Mitch on December 28, 2001, at 18:07:22

In reply to Re: GABITRIL (tiagabine) new anti-anxiety drug????? Mitch, posted by MB on December 28, 2001, at 0:44:40

> Wellbutrin made my eyes blurry too...maybe anticholinergic action? I guess when I said "no anxiety" with the Serzone, I should have said "no increased anxiety," which is still really important. I'll talk to the doc before it's time to start the SSRI and see what he says. So you take the Wellbutrin for seasonal depression? Interesting. I remember that in the early nineties, the consensus was that SAD had something to do with the short days affecting seratonin production (or something like that) and that SSRIs were supposed to be the best for that. Has the consensus changed? I guess it just goes to show that what *works* is more important than whatever psychobiological theory is popular at the time.

Well, what I "heard" about seasonal affective disorder is that the "activating" SSRi's tend to be most effective (Prozac/Zoloft). I took Prozac for several years and it would be very helpful. The trouble is I can't tolerate anything close to a "standard" dose with an SSRI, due to hypomania, GI distress, and insomnia/agitation. I took Adderall two years ago at this time and poof!, no depression at all but I was very edgy, cool, aloof, robotic, etc. Pstims and stim-like AD's work the best for the seasonal depression for me-probably because I can tolerate them a little better. Also, the more sedative SSRi's and TCA's tend to make me very melancholic-very, very blue. Wow, if I could get the effectiveness of Adderall for seasonal depression (and its lack of cycling)without increasing anxiety I would have it made. I would really prefer to not have to take any AD's at all. Just a mood stabilizer and a stimulant. I have thought about Provigil. I wonder if Neurontin+Provigil would be enough? If I can get off AD's my cycling almost quits entirely.

> That's great that the Neurontin works for you. I took it for restless leg syndrom and found no side effect (but no wanted effect either).
> Oh wait, maybe I missed something. Does your seasonal depression have to do with the stress of the holidays or because of the limited daylight?
> MB

I really can map it by how much light there is. I am depressed now, I am just not ruminating and agitated about it. I am just not interesting in doing much of anything. The presence of the holidays makes it worse because there is more stufff to do that I normally would be interested in doing and I don't give a damn. I guess with meds in place it is more of a mild dysthymia/anhedonia thing. Hey, it beats a full-blown depressive episode by a whole lot-I am not going to gripe much. Things have been a whole lot worse than this!





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