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Re: GABITRIL (tiagabine) new anti-anxiety drug????? Mitch

Posted by MB on January 2, 2002, at 23:52:38

In reply to Re: GABITRIL (tiagabine) new anti-anxiety drug????? MB, posted by Mitch on January 2, 2002, at 22:13:55

> > Right now, I'm only on the Trileptal and T4. I'm supposed to add the Prozac soon. Last night was the third night that I took 300 mg of Trileptal. This morning, I really realized how sleepy it is making me. It's not a bad sleepiness. I think antihistamine sleepiness feels *awful*, but this feeling is just kinda relaxing...almost like a benzo...but I worry about being able to go back to school this Monday to continue the year. Yesterday, I spent 14 hrs sleeping. What have you heard through the grapevine; have people been building tolorances to Trileptal sedation?
> Interesting. I felt noticeably *wired* when I was taking Trileptal (a definite stimulant like feeling-I even got up somewhat *early*). Maybe you ought to try 150mg twice daily before you increase to 150mg three times daily??
> Oh BTW, I found Prozac very very activating. It may be that when you add in the Prozac you will see a reversal of the hypersomnia you are seeing now.

Well, at 150 mg, the Trileptal gave me insomnia. Then, when I increased the dose to 300 mg, I didn't notice a change until the third night at that dose, after which I slept 14 hrs. Maybe I'm just catching up on the sleep I missed when I first started taking it. Also, today was the third day without caffeine...that can cause hypersomnia too. I just took my bedtime dose an hour ago (I take it a little early so I can get it in with some food) and I don't notice any sleepiness. Maybe I'm adjusting! All in all, it is really tolorable. I realize how much I disliked the Gabitril!! One weird thing, though: When my last dose started to "kick in" I began to have the physical sensations of a panic attack but it never got too bad...just dissipated

> > Wellbutrin makes me extremely irritable (unless I pop some Xanax when it starts to kick in). I don't know that much about Provigil. I took something called adrafinil (similar to modafinil??) years ago. I don't think I liked was like drinking too much coffee. Do you know the differences between modafinil and adrafinil?
> >
> > MB
> I think that modafinil is a metabolite of adrafanil. I believe the FDA won't let adrafanil in due to liver toxicity concerns.
> I have had *some* irritability attributable to the WB. But, it is very short lived-I don't ruminate/adrenalize for hours afterwards. That is nice because I have taken other meds that increased hostility and I couldn't *put it down* (Effexor, Remeron, Buspar).
> Mitch

What about Adderall, how did it affect hostility/anger? Also, have you heard about the Serzone--liver connection? I just read about that on Medline. I think I may not ask the doc about Serzone after all.





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