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Re: GABITRIL (tiagabine) new anti-anxiety drug????? Elizabeth

Posted by Mitch on December 15, 2001, at 15:24:14

In reply to Re: GABITRIL (tiagabine) new anti-anxiety drug????? 3 Beer Effect, posted by Elizabeth on December 15, 2001, at 11:55:01

> I was interested in this too. Tiagabine is a GABA reuptake inhibitor, so it seems like it should relieve anxiety. Since I need to be on medication to prevent partial seizures anyway, I wanted to find one that might help with other symptoms. But there weren't many responses.
> I'm also interested in Sabril (vigabatrin), which is a GABA transaminase inhibitor (prevents metabolism of GABA by one pathway). Didn't get any responses about this one.
> -elizabeth

I read somewhere that vigabatrain was associated with significant risk of retinal pigmentation. Tiagabine evidently does not have those risks-the article was comparing the two since they elevated GABA via two different mechanisms-there was some concern that tiagabine could have the same problem and it was evidently "cleared" of that concern.





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