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Re: antipsychotics for social p. JahL

Posted by SLS on December 17, 2001, at 7:09:08

In reply to Re: antipsychotics for social p. Elizabeth, posted by JahL on December 16, 2001, at 19:01:11

> > Of course, everybody's different, but I would put antipsychotics way down at the bottom of the list of things to try.

> Except of course Sulpiride & Amisulpride. They're both highly regarded social phobia treatments at Maudsley, England's top psychiatric hospital. Sulpiride is the only med to offer consistent help in this regard for me and I've tried all the conventional options listed.

Hi JahL.

What dosage of sulpiride did you find optimal? A TRD specialist who uses sulpiride recommended 50mg. He also commented that he preferred sulpiride to amisulpride. In his words, he said that "amisulpride is too much an antipsychotic". Amisulpride has a much higher affinity for the DA2 receptor than does sulpiride. Perhaps this accounts for his sentiments.

I have a batch of the stuff. It is incredibly inexpensive. I experienced a "blip" improvement in depression within an hour of my first dose that lasted for a few hours. I was taking only Lamictal at the time. I felt some vague inkling of an improvement during the first week, but I ended up discontinuing sulpiride because the addition of Provigil screwed things up. I wish I had been more patient and methodical. I am often my own worst enemy.

What's interesting about these two drugs is that neither is an antagonist at the 5-HT2 receptors as are Zyprexa, Risperdal, and Geodon. I have a problem with these latter three drugs. I receive a significant improvement from them early in treatment at low dosages. As the effect wanes, increasing the dosages to 5.0mg., 1.5mg., and 60mg. respectively in an attempt to recapture and secure the improvement results in my experiencing unacceptable mind-numbing cognitive side-effects. I feel like I've been hit over the head with a baseball bat. I am suspicious that this is due to the 5-HT2 blockade. When the time comes to again try adding a neuroleptic, I think I'll give sulpiride a try.

Why did you stop taking sulpiride?

- Scott




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