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Re: GABITRIL (tiagabine) new anti-anxiety drug????? 3 Beer Effect

Posted by Mitch on December 15, 2001, at 10:11:40

In reply to GABITRIL (tiagabine) new anti-anxiety drug?????, posted by 3 Beer Effect on December 14, 2001, at 22:42:11

> GABITRIL Filmtab Tablets (tiagabine hcl), Abbott Laboratories, PDR p. 449 is an antiepilepsy drug available in 2, 4, 12, 16, & 20 mg tablets. Antiseizure effect of Gabitril from enhancement of activity of GABA, inhibition of GABA uptake into presynaptic neurons which permits more GABA to be available for receptor binding on the surfaces of post-synaptic cells, & increases amount of GABA available in th extracellular space of the globus pallidus, ventral palladum & sustantia negra. This suggests that tiagabine prevents the propagation of neural impulses that contribute to seizures by a GABA-ergic action.
> This drug sounds like it would make a great anti-anxiety drug, since like the benzodiazepine Klonopin it enhances the effect of GABA and it an anti-convulsant and GABATRIL is not a controlled substance like the Benzodiazpines.
> Also, it appears to be superior to Neurontin since Gabitril acts directly on GABA while Neurontin is structurally related to GABA but it is not converted into GABA, or a GABA agonist, does not interact w/ GABA receptors & it is not an inhibitor of GABA uptake or degredation.
> Does anyone have any experience with GABATRIL and/or can comment about its anti-anxiety/social phobia potential?
> Thanks, 3 Beer Effect

I took it for a few weeks for bipolar as a mood stabilizer. It seemed to have more of an antidepressant effect (at lower doses) than an antianxiety effect. It seemed ok for sleep. I found Neurontin or Depakote or Topamax had a better anti-anxiety effect of the anticonvulsants I have taken.





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