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Re: ketoconazole SLS

Posted by Elizabeth on September 25, 2001, at 0:40:01

In reply to Re: I think you might benefit from ketoconazole Elizabeth, posted by SLS on September 24, 2001, at 22:39:19

> Hi Elizabeth.

Hi there.

> How would you characterize the quality of the antidepressant response produced by ketoconazole?

This I don't know. I never tried it, although I keep meaning to bring it up to my pdoc.

> What would you guess to be the percentage of people would respond to it. I'm a non-suppressor to the DST.

If you look in the literature, you may find mixed results. I think this is misleading. If you look only at the subset of depressed patients who are DST nonsupressors, antiglucocorticoids are pretty effective. (I have no idea how ketoconazole compares to other antiglucocorticoids.) Based on the existing data, it's hard to come up with a number, but I would expect nearly all DST nonsuppressors to show at least a partial response (certainly in this subset of patients I'd expect a higher response rate than is seen in depressed patients in general to typical AD therapy). This is just a guess, of course, so take it with a big grain of salt.





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