Posted by kregpark@yahoo.com on September 5, 2001, at 1:44:34
In reply to Re: (Dopamine and SP... and) a *Complaint* » kregpark@yahoo.com, posted by Rick on September 3, 2001, at 4:18:29
Interesting post Rick!
I see your points. I agree with some and I also
kind of still like the Versiani article.
I guess I still like the
article simply because it seems to me a "classic"
and I think still mostly accurate. I think the
upper range of 6mg is ok (I took 5 at times without
problem with Zoloft + Serzone) - but the low end
could probably be 1 or 2.Some points like "disinhibition" I definitely
experinced myself. Even Gorman's classic book
points out disinhibition citing examples such
as "arguing with the boss" and "driving recklessly"
I myself have done the former (a few times during
washouts of MAOI's!!! while on Klonopin alone!!)
and once did drive a bit recklessly when out a long
time at night and taking a bit too much Klonopin
early in my fantastic discovery of it.I think panic disorder patients probably use less
with good results than SP - different disorders.Also, I think that those taking *solely* Klonopin
alone will get by with a bit of a lower dose. Mine
didn't vary more than about 20% though alone versus
in combos.I think in my case that some drugs either "add"
to the effective Klonopin effect. Examples for
me coming to mind are Provigil or Prov+Serzone, and
Gabapentin. Tramadol also comes to mind.Provigil seems unique to me that it has stimulant
effects and seems to boost the effect of a given
Klonopin dose without the expected side effects
of that dose.I have experienced it before though - in the short
run, with Ritalin and Dexedrine, both strongly
dopaminergic.Craig
> First of all, the article is becoming dated. Nothing wrong with that in and of itself, but it seems as if the "Social Phobia" link is just languishing there with no real attention given to it. It's basically an anecdotal report, not a rigorous study of any kind, when in fact several excellent and even pivotal studies on Klonopin for SP -- some of them placebo-controlled -- do exist. Heck, the Brazilian write-up even ends by saying their approach is under review! So, what did the review conclude??
>
> Secondly, it does a disservice by dwelling on supposed Klonopin-driven disinhibtion episodes that I'm sure are not very typical. Some uninformed people who take that article at face value will probably stay away from Klonopin because they fear a personality change that will turn them into gun-toting gangsters like that one social phobic-turned-thug the authors cite.
>
> Worst of all is the article's claiming 3-6 mg/day as the typical effective dosage range for Klonopin in Social Phobia. Frankly, I find it bordering on irresponsible to leave an article on the site that cites a MUCH higher than typical range as "average". Certainly , there are more than a few people who do better on a higher dose (I believe you said you take about 4 mg yourself -- which is still a lot less than 6), but any cursory review of posts on this board or others, or discussions with medical professionals, will tell you that most people do best on 3mg or less, and that a great many do just fine on 1 mg/day or less. And yes, I realize that body weight can make a difference, and that perhaps Brazilian clonazepam is less potent as a poster once suggested (although I tend to doubt that's the case).
.... >
> Rick
poster:kregpark@yahoo.com
thread:36517
URL: http://www.dr-bob.org/babble/20010902/msgs/77782.html