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Re: DOPAMINE - SP and Parkinsons Disease » Mitch

Posted by kregpark@yahoo.com on September 7, 2001, at 2:36:01

In reply to Re: DOPAMINE - SP and Parkinsons Disease » Rick, posted by Mitch on September 7, 2001, at 1:37:20

General comment: It is a pleasure to read these
posts! I've not looked at Internet group exchange
on SP for a couple years, and never before was a
big fan, but I am really learning a lot here on this
board! Very interesting and informative and
sharing posts. Thanks to everybody and I suppose
especially Dr. Bob for setting up (and even
monitering for rude comments like one I made!! :)
to help keep the board clean.)

I'm tired but wanted to comment briefly on the
last posts...

Mitch:

I have tried Mirapex also, those I'm never heard
of Permex ... Although my symtoms obviously are
much different overall from yours, I wanted to just
throw in my reaction to Mirapex. To me I did not
feel good when taking it in a starting very low
dose even (as recommended). Hard to describe; it
was sort of alerting and sedating at the same time
which makes no sense probably. Maybe something like
mentally alert and physically sedated or something.
Also queasy feeling which some dopaminergics can
cause. I was enthusiastic about trying it but
quickly lost interest and threw it away.

Of course for lots of people it will be useful but
that was just my own experience as one with
primarily (if untreated) severe SP and probably dysthmia.

I agree with Rick about the Provigil.
Rick's comment about the Provigil antidepressant
augmentation and particularly positive response in bipolar low
patients is right on. I recall that now after he
mentioned it. (I just happened to read that article
a few days ago.. it is one of the 10 or so journal
articles I have kept a copy of ... ) I would never
have thought of that though until Rick mentioned it.

Very sleepy for a change ... (Nardil + Provigil
leads to 5.5 hours sleep for me on average),
so will stop here...

kregpark

> >
> > Have you by any chance already tried Provigil or its overseas cousin adrafinil?
>
> No, I haven't. I have tried Permax and Mirapex. Liked the Permax better. May be retrying that one sometime soon. I will read up on the Provigil/Adrafinil
>
> >
> > BTW, I once saw an abstract where a doctor (or group of doctors) claimed to have determined that having a tremore side effect on an SSRI indicates that the patient is someone who will probably develop Parkinsons at some point (I think it WAS worded that strongly, can't swear to it). I'm a bit skeptical about this, at least in terms of the *degree* of correlation claimed.
> >
> > Rick
>
> Gee, say it isn't so, but I wouldn't be too surprised. Haven't got PD in the family, which is a plus. Just epilepsy, thyroid, ADHD, and bipolar though.


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poster:kregpark@yahoo.com thread:36517
URL: http://www.dr-bob.org/babble/20010902/msgs/78126.html