Posted by kregpark@yahoo.com on September 3, 2001, at 3:00:15
In reply to Re:SP Cocktail/Mechanisms of Action/Memory Culprit » Rick, posted by kregpark@yahoo.com on September 3, 2001, at 2:43:13
Provigil and dopamine:
1) If provigil is NOT dopaminergic, I believe
it would be the only potent wakeful agent
that does not enhance dopamine function.
(gaba inhibitor would do this but would
of course enhance dopamine and other
neurotransmitter function)Dopamine studies in rats:
1) "Social leaders" among rats have highest dopamine levels.
2) "Most passive" rats have lowest dopamine levels
3) Rats general socialability directly linked to dopamine levels.
4) Rats sexual activity and "success" positively correlated to dopamine levels.
Dopamine and rejection sensivity:Atypical Depression has a key feature of high sensitivity to rejection.
(Social phobia also has this as a key feature).
BOTH condition respond VERY WELL to Nardil, BUT
do NOT respond (especially SP) to tricyclics.
The known difference is a lack of dopaminergic
effect in tricylics (Liebowitz)I will add a few links later at http://socialfear.com
There is a nice abstact quite recent called suggesting
that serotonin, dopamine, and gaba probably all play a
role in a substantial number of SP cases.
poster:kregpark@yahoo.com
thread:36517
URL: http://www.dr-bob.org/babble/20010902/msgs/77502.html