Posted by MB on July 11, 2001, at 18:30:34
In reply to Re: Weight gain and SSRIs » MB, posted by Elizabeth on July 11, 2001, at 15:38:17
> There's a guy at MIT (well, I'm not sure if he's still there) who was really trying to push the serotonin-carb connection hypothesis (he had a major interest in Redux, of course).
Doesn't Meridia work on Serotonin? I just watched an online video called "Metabolic effects of Atypical Antipsychotics"(check it out if you haven't already: http://www.mentalhealth.ucla.edu/opce/gr.html ). It mentioned antagonism of 5HT-2c as a possible mechanism for neuroleptic weight gain. It also mentioned that stimulation of this site might lead to appetite reduction...in fact, I think the guy stated that this was the puted mechanism of Meridia. Anyway, it's interesting that Meridia was originally tested as an antidepressant. I assume that the action of SSRIs indirectly leads to stimulation of the 5H-2c sites in the brain. I wonder why they make people fat...
> Thing is, this idea doesn't explain why so many depressives stop eating and lose interest in food (carbohydrate or otherwise)!
I gorge myself when I'm dysthymic or anxious, but I barely eat when i'm *really* depressed. I think I might be atypical (eat and go to bed when my mood is low). However, I am *worse* in the morning and sometimes peaceful and euphoric at night (calm, not manic...although I *did* think I was Buddha one time). That would go against an atypical dx, wouldn't it?
> I didn't lose weight on Prozac, but I didn't gain back the weight I'd lost while depressed. Paxil seems to be worse than the other SSRIs as far as causing weight gain.
Yeah, I gained about 30lbs while taking Paxil. I've gotten my body fat back down to about where it was before I started, but my body is just stockier and heavier...shaped differntly...it's like the Paxil just permanently changed my body type, or something. Or, maybe it's just hitting 30 yrs old that did it.