Posted by Elizabeth on July 16, 2001, at 18:31:45
In reply to Re: Weight gain and SSRIs » Elizabeth, posted by MB on July 16, 2001, at 1:22:19
> > Sibutramine is very long-acting -- you'd only have to take it once a day.
> Hmmm...I wonder what he was talking about, then.
Hmmm back atcha. < g > I'm looking at the PI, and it seems that I was wrong about the elimination half-life (it's only an hour or so). It might be that (like other diet pills) it mainly works in the first few weeks (at most) so steady-state levels aren't an issue. The recommended dosing schedule is once daily.
> Have you had a chance to watch that video about the metabolic effects of atypical antidepressants?
Which video? Did I miss something?
> The way the commercial goes: "...people who abuse Meridia may become dependent," I thought this stuff was like an amphetamine or something. Why do you think they're treating it like this?
My guess: because it's marketed as a diet pill and because some of the preclinical trials showed signs of abuse potential in animal models. There are always some false positives in those models, though.
> I think some people can actually *lose* weight on Moban!
If only in virtue of having gotten off of other antipsychotic drugs.
Moban did something totally weird to me when I tried it. I wasn't asleep (I was taking it for insomnia), but I was totally immobilised. Not comfortable!
> Negative symptoms...like flat affect, etc?
> It will be interesting to see what the outcome of the drug's use is in the long term. I remember when there was discussion in the late eighties (and early nineties) about using SSRIs as diet drugs...whoops!
I think that "d'oh!" is the appropriate expression here.
> No, of course not...but can it be figured out? If the brain were simple enough to be figured out, would the mind of such a brain be intellegent enough to do the figuring? Did that make any sense? wait...huh...? ;-P
That's a claim that has been made by some: that we can't use our own consciousness to understand that consciousness. (I don't buy it, of course.)
> I think treatment plans need to be highly individualized
That's true. Everybody's different. (I don't think this is unique to psychiatry.)
> > Yeah. You know, migraine has pretty much been redefined as any headache that responds to sumatriptan!
> That's kinda funny...but if it works and helps people get well...why not use that definition?
That's mostly my general feeling, too.