Posted by Stagalee on May 15, 2001, at 15:41:23
In reply to Re: Serzone, posted by JennyR on May 20, 2000, at 21:40:52
A few folks have mentioned that twice a day or even four times a day dosing is indicated given Serzone's short half life. While the parent compound does have a short half life, it has some active metabolites that clear more slowly, and you achieve a steady state (essentially a plateau concentration, or rising and falling levels above and below a plateau) 3-4 days after starting or changing the dose. The fact that you can reach steady state even taking it once a day implies that you will not have periods with no drug on board. See:
http://www.mentalhealth.com/drug/p30-n05.html
I am taking it once a day and had a terrible reaction to 100 mg the first night, but after dropping back to 50 mg a day for 3 days was able to tolerate 100 mg just fine. Slow dose escalation is definitely a good idea, and whether you ultimately choose once or twice a day should depend on your personal reaction, e.g. people who feel fuzzy and sleepy may do better with one dose in the evening, and those who like its anxiolytic effect in the morning and can tolerate it may wish to split the dose.
poster:Stagalee
thread:33730
URL: http://www.dr-bob.org/babble/20010515/msgs/63124.html