Posted by steve on March 18, 2001, at 2:05:08
In reply to Re: ADVICE PLEASE-Want to try Geodon, but TD risk? » steve, posted by JohnX on March 17, 2001, at 7:20:02
John,
The reason I suggested you ask about freebies, is not because I think they are totally illegitimate, but rather because I think they are abused.
There was a relatively recent article in my home town paper about how medical anonymity is totally gone. Pharmacies routinely sell info about who buys what from them. A psychiatrist was quoted as saying that one day a sales rep had walked into her office, and given her a list of her patients on competitor's drugs, and wanted to discuss why the patients couldn't be changed to their product, (which makes me think they were flogging the "atypicals".) Though that might be crass, the crassest part is that some companies adjust their freebies according to how much "product" they prescribe. I think this creates an enormous potential for conflict, and I think "consumers" should be aware of this.
S.
> > >
> > > > I really don't think your shrink is doing you a favor by suggesting that TD is something one either has or doesn't have. TD is caused by the APDs killing neurons off, which they all do by their very mode of action. The only unknown is if it the neurotoxicity will suffice to inflict disabling neurological damage or not. A much better analogy would be say with lead poisoning, which some times does cause substantial CNS disturbacnes, and sometimes kills, but not always either.
> > > > > S.
> > >
> > >
> > > I thought TD was primarily caused by a lack of dopamine or blockade of D2 receptors spawning more D2 receptors? The inclusion of 5ht-2 antagonists in newer anti-psychotics was to increase the dopamine release in those receptors sensitive to TD.
> > >
> > > -John
> >
> > That theory is no longer operative. Current thinking is that TD is when the brain damage reaches a critical mass. There might be a case to be made for the treatment, but the fact remains that it does cause brain damage.
> >
> > S.
>
> Hi,
>
> Can you please provide any links to studies that abort the old theory of TD? This must be relatively new data because all the information I have is mainly from the last 3 years or so and most of it points to the "old" theory.
>
> In a brief summary if possible:
>
> -What kind of neurotoxic transmission is thought
> to cause the TD?
>
> -Why do the newer anti-psychotics with 5-ht2
> antagonism have reduced TD given the old
> theory is bunk?
>
> I would really appreciate any information as this
> is an important criteria in my medical decisions.
>
> Thanks,
> John
>
poster:steve
thread:56412
URL: http://www.dr-bob.org/babble/20010310/msgs/56818.html