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Re: ADVICE PLEASE-Want to try Geodon, but TD risk?

Posted by steve on March 16, 2001, at 3:51:38

In reply to Re: ADVICE PLEASE-Want to try Geodon, but TD risk? » steve, posted by JohnX on March 15, 2001, at 23:36:26

>
> > I really don't think your shrink is doing you a favor by suggesting that TD is something one either has or doesn't have. TD is caused by the APDs killing neurons off, which they all do by their very mode of action. The only unknown is if it the neurotoxicity will suffice to inflict disabling neurological damage or not. A much better analogy would be say with lead poisoning, which some times does cause substantial CNS disturbacnes, and sometimes kills, but not always either.
> > > S.
>
>
> I thought TD was primarily caused by a lack of dopamine or blockade of D2 receptors spawning more D2 receptors? The inclusion of 5ht-2 antagonists in newer anti-psychotics was to increase the dopamine release in those receptors sensitive to TD.
>
> -John

That theory is no longer operative. Current thinking is that TD is when the brain damage reaches a critical mass. There might be a case to be made for the treatment, but the fact remains that it does cause brain damage.

S.


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URL: http://www.dr-bob.org/babble/20010310/msgs/56632.html