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Re: Educated Guess?/Poop Out

Posted by AndrewB on March 16, 2000, at 10:58:16

In reply to Re: Educated Guess?/Amineptine, posted by Scott L. Schofield on March 16, 2000, at 7:35:17

A couple comments I wanted to add here.......

SSRI poop out can also be caused by dopamine depletion. For more info. see Dr. Bob's Tips section. Signs to look for in dopamine depletion are: fatigue, mental fatigue (poor memory, poor concentration), sleepiness, apathy, anhedonia. Remedies include dopamine activity enhancers, ideally D2-D3 receptor enhancers, such as the amino acid dopamine precurosor Tyrosine, the D2 agonist Bromocryptine, amisulpride and Mirapex.

Scott, it's my impression also that Wellbutrin has mainly NE activity. I have tried or am using Wellbutrin, Reboxetine, amineptine , Mirapex, and amisulpride so I should be able to tell the difference between NE and dopamine action. I've read contradicting info. on Wellbutrin's supposed dopamine effects so maybe academia is not in agreement on what Wellbutrin actually acts on (and to what degree). By the way Scott, thank you for your imformative (and entertaining) posts, I've learned a lot from you over the months.

Final note, I've been on the combo of amisulpride and Mirapex (also take reboxetine) for 10 days. Good effect, all of amisulpride's effects have been enhanced; euthymia, the anxiolytic effect, the motivation and energy. Too early to tell if this will work long term though, as you noted a while back Scott, dopamine agonists may tend to poop out. Amisulpride and Mirapex are the combination of a presynaptic D2-D3 antagonist with a (postsynaptic) D2-D3 agonist. I guess this enhances dopaminergic activity sort of like plugging the dike and filling the pond.

AndrewB



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