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Re: Nortrip, Wellbutrin & Prozac -- Oh MY!

Posted by Scott L. Schofield on December 29, 1999, at 13:36:38

In reply to Nortrip, Wellbutrin & Prozac -- Oh MY!, posted by Bob (back from the overworked_dead) on December 24, 1999, at 10:34:14

> Sorry, I can't remember who was asking about how sedating Nortrip was. I've taken zoloft, prozac, paxil, zyprexa, ativan, clonazepam, and perphenazine and only the perphenazine has been more sedating (damn well better be, too, as an anti-psychotic!). It also wound up doing more for me than 200mg/d of zoloft. I'm at the lowest therapeutic dose, 75mg/d, and my nortrip blood level is 3 points into the therapeutic range (50-150), and it's been more effective than any SSRI for me. Again, it has been quite sedating, so that's one reason why I wanted to mix in some wellbutrin rather than boosting my nortrip dosage. Besides, the sedation is the only side effect I've had from the nortrip ... no point tempting fate by going up to a higher level.

I guess the sedation experienced with nortriptyline (Pamelor) is a carry-over of sorts from its parent compound, amitriptyline (Elavil). Amitriptyline really sucks as far as sedation is concerned. It felt like I was encased in blob of sludge. This sedation/malaise did not wear off appreciably over the course of six weeks. On the other hand, I found that the sedation I experienced with nortriptyline abated over time. I guess it took between one and two weeks.

It's a good drug worth sticking with.

- Scott




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