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How about Nortrip and Prozac ?

Posted by Andy on December 20, 1999, at 9:42:47

In reply to Re: Nortrip/Wellbutrin Combo, posted by JohnL on December 17, 1999, at 3:16:21

Hello again John L

Prozac is a miracle drug for my depression I need 50mg. If I was on prozac alone the side effects of anxiety and insomnia would make it intolerable. Buspar 60mg gets the anxiety under control, with additional benefits as well. Insomnia continues to be a real problem.

A couple of months ago I posted a query looking for augmentation strategy that could help me reduce the prozac. Ended up with Naltrexone. Naltrex made me calmer and did improve sleep. It did not permit me to lower the prozac as I had hoped. I am not entirely satisfied with it because it causes fatigue and seems to require that I sleep 10-11 hours a night to feel moderately rested. I'm going without it for a while.

Thoughts on adding Nortrip to the mix with the objective of improving sleep and possibly getting by on less prozac ?

What's the story with weight gain ?

> > Hi again Bob. No experience here with the two combined. However I did read an abstract describing the combination used successfully for refractory depression. It seems like it should be a great combination. JohnL
> OK, so this got my interest. I am now taking Nortrip+Wellbutrin and we'll see how it goes. Prozac+whatever was useless on my anhedonia/melancholia after a year of trying. I saw another abstract that showed that patients experiencing melancholia while on SSRIs responded when switched to Nortrip, Wellbutrin, or ECT. Clearly it seems the melancholic subtype requires a different approach than other forms of depression. Lots of research and anecdotal evidence seems to support TCAs or Wellbutrin or both over SSRIs for melancholic depression. If the measuring criteria is 50% reduction of Hamilton depression score, all antidepressants are equally effective. But if the criteria is changed to a more stringent requirement of 10 points or less on the Hamilton score, TCAs blow SSRIs in the weeds.
> This is the route my psychiatrist has always wanted me to take, but I couldn't because of severe tinnitus on Wellbutrin. What I have discovered is that Wellbutrin does not produce tinnitus since the Remeron was removed. Something about that combo caused severe tinnitus. Strange. I am taking 50mg of Lamictal too, which seems to be a factor in quieting the tinnitus. And I plan on continuing Prozac, perhaps 20mg every three days or so, just because.
> So, Nortrip+Wellbutrin it is, with a sprinkle of Lamictal and Prozac in the background for tinnitus control. So far the only side effects are dry mouth and insomnia. Nortrip has always seemed quite sedating to me, but Wellbutrin overcomes that strongly enough to cause insomnia. Hope that passes. In theory this seems like an excellent combo for melancholia in a sexually active patient. We'll see. So far so good. Thanks for starting this thread. I was in need of more ideas after abandoning Remeron. :) JohnL




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