Psycho-Babble Medication | about biological treatments | Framed
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Re: Nortriptyline

Posted by JohnL on December 13, 1999, at 4:23:29

In reply to Re: Nortriptyline, posted by Bob on December 12, 1999, at 21:51:44

I'm still seeing Ann Hedonia ;^) more than my girlfriend as well. So there's much room for improvement.
> All the same, my latest soapbox here in Babbleland is how TCAs are as dirty for some of us as Common Wisdom would have us believe.
> Bob

I know Ann too! I know her all too well. She hangs around with me 24 hours a day. Wish I could just tell that *&%^*% to get lost.

One comment on Nortriptyline. It has a rather narrow therapeutic window. I saw a graph on Nortrip that was the shape of a bell curve. Response to this drug is in the narrow range at the top of that bell curve. Doses to the left (too low) and doses to the right (too high) produced profoundly diminished response. It might be a good idea to get a blood test to measure your current plasma level of Nortrip to see whether your dose is too low. The correct levels are well known and documented. So your doc and/or the place that does the testing should be able to tell you where your dose stands at this time.

I'm finally off Remeron (that was a hard thing to get off of, almost like an addiction), and don't really like the benzo Xanax much, so yesterday I took some leftover Nortrip just out of curiosity. (insomnia issue) I slept OK, but I was surprised yet puzzled at the lack of side effects with a one-time 50mg dose. I remember when I used to take it with Zoloft it was incredibly sedating. It was just a one time one day dose yesterday, but it was much smoother than a one time one day dose of anything else I can think of I've ever tried. Didn't seem 'dirty' at all. My pdoc wants to add Desipramine to my Prozac in a couple weeks, but heck, with all this leftover Nortrip and lack of side effects, maybe I'll just keep going with it and see how things develop. But then again, back to the first part of this post, I too would have to get the dose into that narrow therapeutic range. That's even trickier when mixed with Prozac. Desipramine on the other hand has a linear response without that narrow window. Just didn't know if you were aware of Nortrip's narrow therapeutic window. FYI. JohnL




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