Posted by Zeke on December 14, 1999, at 11:25:55
In reply to Re: Parnate: weight gain, & the literature - Liz, posted by Elizabeth on December 14, 1999, at 4:44:22
> > (Interestingly, is the Surgeon General's report documenting people not seeking help for psychiatric disorders.
>
> I can't find this...happen to have a URL?
>http://www.nytimes.com/library/politics/121399mental-health.html
> >Gee guys, we take away the tools and what do you expect. We've already removed the promising application of MDMA in psychotherapy because of morally biased research.)
>
> You know, I really don't think that opposing use oof certain types of drugs has anything to do with morality. Maybe that's just my own moral bias, though!
>I'm not talking about people taking ecstasy every weekend at the local rave -- though that's the reason it's schedule 1. I'm talking about limited clinical use to augment therapy just as pindolol augments Prozac. When I say morality, I mean the government passing along research that supports its view and withholding research that doesn't, or even preventing research in the first place. I get upset when they rant that 'MDMA destroys serotonin neurons," but never mention that administration of an SSRI four hours later will block the uptake and damage. I'm sorry, I just get upset when moral prejudice strongarms block scientific discovery. And remember that many of these folks would like to cast all psych meds in to the sea -- ' and by God, you should just pull yourself up by your bootstraps!'
> > IMHO Parnate is also mainly for refractory depression:
> >
> > "Tranylcypromine in high doses (20 to 30 mg po bid) is often effective for depression refractory to sequential trials of other antidepressants; it should be administered by physicians experienced in the use of MAOIs."
> > --The Merck Manual
>
> True, that's what I use MAOIs for (haven't given tricyclics an adequate trial due to side effects, though).Despite all the bliss, I think the side effects of SSRIs cause many to drop those too. I can't deal with higher doses of Luvox but use a lower dose and pindolol.
>
> > > Uhh... "There are no cases of tranylcypromine-induced weight gain in the literature that are clearly associated with the drug." (This was after the drug had been approved in this country for nearly 30 years.)
> >
> > With emphasis on the word 'clearly.'
>
> I think that's what I'd require to consider it real evidence that Parnate "causes" or "induces" weight gain.
>OK, with emphasis on no case being clear to this particular researcher.
> > > No doubt the appetite reduction helps, though my appetite increased on Parnate (probably secondary to remission of depression!).
> >
> > Remember that increased appetite (especially carbo cravings) are a symptom of atypical depression, just as weight gain is!
>
> Well yeah, I thought that was where the weight gain came from! Eating junk food, especially at night.
>
> > You might find this one interesting
> >
> > Richard J. Wurtman and Juidith J. Wurtman
> > Carbohydrates and Depression
> > SCIENTIFIC AMERICAN January 1989
> > http://www.sciam.com/0189issue/0189wurtman.html
>
> Oh god, not the Wurtmans!If I'd only know you were from Boston! (Besides, RW's a good guy -- Now if I'd have said John Mack... Beam me up Scotty!)
poster:Zeke
thread:9748
URL: http://www.dr-bob.org/babble/19991212/msgs/16902.html