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Re: Parnate: weight gain, & the literature - Liz

Posted by Elizabeth on December 14, 1999, at 4:44:22

In reply to Re: Parnate: weight gain, & the literature - Liz, posted by Zeke on December 14, 1999, at 1:39:09

> > :-) Well I *did* say "AFAIK." You can't argue that I knew of documented weight gain with Parnate! :-)
> >
> You're a tough sell -- probably from Missouri -- but I respect that!

Not even close - Boston. :)

> General references like the PDR and the Merck Manual (and especially the watered down popular books) tend to generalize the MOAIs and use the same profile for all.

Yeah, I know. Among my many flames about such references. :)

> Well among other things, the DEA is keeping an eye on Parnate and its derivatives for abuse potential.

I guess they wonder about it too. There *have* been reports of that in the literature (and in people, too!).


> (Interestingly, is the Surgeon General's report documenting people not seeking help for psychiatric disorders.

I can't find this...happen to have a URL?

>Gee guys, we take away the tools and what do you expect. We've already removed the promising application of MDMA in psychotherapy because of morally biased research.)

You know, I really don't think that opposing use oof certain types of drugs has anything to do with morality. Maybe that's just my own moral bias, though!

> IMHO Parnate is also mainly for refractory depression:
> "Tranylcypromine in high doses (20 to 30 mg po bid) is often effective for depression refractory to sequential trials of other antidepressants; it should be administered by physicians experienced in the use of MAOIs."
> --The Merck Manual

True, that's what I use MAOIs for (haven't given tricyclics an adequate trial due to side effects, though).

> > Uhh... "There are no cases of tranylcypromine-induced weight gain in the literature that are clearly associated with the drug." (This was after the drug had been approved in this country for nearly 30 years.)
> With emphasis on the word 'clearly.'

I think that's what I'd require to consider it real evidence that Parnate "causes" or "induces" weight gain.

> > No doubt the appetite reduction helps, though my appetite increased on Parnate (probably secondary to remission of depression!).
> Remember that increased appetite (especially carbo cravings) are a symptom of atypical depression, just as weight gain is!

Well yeah, I thought that was where the weight gain came from! Eating junk food, especially at night.

> You might find this one interesting
> Richard J. Wurtman and Juidith J. Wurtman
> Carbohydrates and Depression

Oh god, not the Wurtmans!




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