Posted by JohnL on August 24, 1999, at 4:22:48
In reply to Re: SAMe, posted by gail on August 24, 1999, at 0:03:57
Hi all. Here is my attempt at some answers to your questions. For me, SAMe has some energizing effect on the first day, but seems to make a more substantial difference during a difficult time on about day 3.
It is a natural body compound reproduced synthetically in pill form to increase body levels of it. It is an important chemical in nearly all body functions, especially brain function, liver function, and healing. It basically supplies donar molecules needed for all kinds of natural body chemical reactions to take place. I'm not sure it's mechanism in depression is known, but theory says it boosts neurotransmitter production and repair. It has been used in Europe a long time and is popular there. Lots of research studies on its effectiveness and safety.
Yes it can be taken with Celexa, or any AD, except perhaps the MAOIs. Not sure about the MAOIs. The only risk I've read about is possible mania, but that risk is present with just about anything. Theoretically it may help the SSRI or TCA work better and faster, possibly allowing a lower dose. I find its only drawback is the cost. About $1.00 a pill, with 4 to 8 pills needed per day on empty stomach. If mixed with food, it is broken down before being absorbed in the body.
For me, it definitely helps the Prozac work better, but again, nothing magical, just helpful. If it wasn't so darn expensive I'ld take more of it. I do support its use for quick relief. I don't think it will cure a depression, but it lifts one at least halfway out of the hole very fast. Like anything else, it is statistically helpful in about 70% of those who try it. Hope this helps. JohnL.
poster:JohnL
thread:10560
URL: http://www.dr-bob.org/babble/19990829/msgs/10608.html