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Re: Serzone +Buspar warning confirmed

Posted by Elizabeth on July 13, 1999, at 21:25:29

In reply to Re: Serzone +Buspar warning confirmed, posted by elizabeth on July 13, 1999, at 15:46:13


I didn't understand all of the medical terminology relating to the interaction between Buspar and Nefazodone. Could you possibly explain it in non-medicalese?

> According to the updated PI, Buspar is metabolized into 1-pyrimidinylpiperazine (1-PP) by CYP3A4, an enzyme inhibited by nefazodone. Therefore, buspirone levels will be higher and 1-PP levels lower if Buspar and Serzone are taken together.

> Therefore, they recommend starting at a very low dose of Buspar (i.e., starting at 2.5mg bid) if you're on Serzone as well.

Does this mean that you can take Buspar with Serzone?

Thanks for the clarification, I am really confused about this and don't feel comfortable talking to my doctor (fairly obvious from my last post).





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