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Add pindolol to serzone, wellbutrin and cytomel

Posted by Ash on June 2, 1999, at 11:01:08

Hello everyone,

I am on of those treatment-resistant depressives ( 50 yo male) who has tried a multitude of medications over the last 19 years. Nothing has worked for the depression, although some medications have helped to the extent that I am able to be somewhat functional instead of staying in bed all day.

My current regimen is 3x150 mg/day of Serzone along with Wellbutrin SR 3x100mg. The latter was added by my pdoc to give me some more energy during the day. For hypothyroidism, I take 100mcg of Synthroid(T4) together with 10mcg of Cytomel(T3) prescribed by my endo doc. This combo has had a noticeable improvement in my feeling of lethargy although the effect on the depression has been marginal at best.

To boost the A/D effect, my pdoc and I have been considering various approaches. My endocronologist (head of internal medicine at a University hospital) will not permit an increase in T3 to 25-50mcg, as he says that recent studies have shown that adding too much T3 has a long term deleterious effect on the incidence of coronary disease. Previously I was on 25mcg of T3 for a few months with no noticeable improvements. Boosting the WB SR dose is also out because of a previous seizure on high doses of WB. Finally more Serzone makes me too sleepy.

We come now to the other augentation agsnts, of which Pindolol seems to be among the more popular ones among pdocs. My questions are : Is there any reason I should avoid adding Pindolol to my drug cocktail? Anyone with experience with this or a similar comnbination? Any other approaches anyone can suggest?

Thanks in advance.





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