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Re: Serzone +Buspar warning confirmed

Posted by elizabeth on July 13, 1999, at 15:46:13

In reply to Serzone +Buspar warning confirmed, posted by Erin on July 13, 1999, at 1:29:10

Ahh, thank you Erin. This is important to know, since Serzone is often prescribed for anxiety or anxious depression, and Buspar is labelled for anxiety.

According to the updated PI, Buspar is metabolized into 1-pyrimidinylpiperazine (1-PP) by CYP3A4, an enzyme inhibited by nefazodone. Therefore, buspirone levels will be higher and 1-PP levels lower if Buspar and Serzone are taken together. Therefore, they recommend starting at a very low dose of Buspar (i.e., starting at 2.5mg bid) if you're on Serzone as well.




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