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Re: Prozac with Serzone. More questions???

Posted by Mark on May 10, 1999, at 5:19:05

In reply to Re: Prozac with Serzone. More questions???, posted by steve on December 31, 1998, at 2:02:21

The side effects of SSRI's are thought to be based
on serotonin, and perhaps specifically on
activation of the serotonin receptor subtype 2
and 3. Serzone and trazodone specifically
block the serotonin 2 receptor. Serzone
increases serotonin (like SSRI's) while
blocking the troublesome serotonin 2 receptor.
Somehow, blocking this receptor also seems
to have antidepressant efficacy.

> How does this work? That is, how does Serzone counteract the side-effects of Prozac (especially sexual -- it seems to me that increases in seretonin- the neurotransmitter that is responsible for sedity, will also dimisnish libido).




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