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Re: Prozac with Serzone (Steve & Michael)

Posted by Elizabeth on May 10, 1999, at 8:40:08

In reply to Re: Prozac with Serzone (Steve & Michael), posted by Nick on May 9, 1999, at 12:55:20

>The reason I ask is that sometimes the
>combination leads to the acumulation of a
>nefazadone metabolite mCPP, which can be
>extremely provoking of anxiety symptoms. I
>*think* this happens because of metabolic
>pathway inhibition by the prozac.

Yeah, I do think that CYP2D6 is responsible for metabolism of mCPP.

Would sertraline, citalopram, or venlafaxine be safer choices to use with Serzone? And come to think of it, does this problem ever pop up with trazodone (commonly used with Prozac, Paxil, etc. for insomnia)?




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