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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Amigan on July 6, 2008, at 19:19:54
Hi.
I'm looking for a med which is a 5-ht2a/2c antagonist, but without having any adrenergic action like Mirtazapine and Trazodone.
For example, trazodone doesn't work very well for me. It sedates me somewhat, but less than most people reports. If i take a decent dose, i develop tachycardia which interferes with my sleep and although i feel sedated there is a feeling of tension. It's the noradrenergic action of Trazodone that gets in the way and ruins its effectiveness as a sleeping aid!...
If i would have to choose between Trazodone and a antihistamine like Phenergan to knock me off to sleep, i would choose Phenergan right away. Much more effective for me.
As for Mirtazapine, i have never tried it, i know that it has antihistaminic action which is very good, but i read that it uses the same mechanism to increase noradrenaline.So, does this drug exists or should i have to take my Trazodone with clonidine?
Posted by Sigismund on July 7, 2008, at 3:21:25
In reply to Looking for a med with these specifications, posted by Amigan on July 6, 2008, at 19:19:54
I dunno anything about this, but what about cyproheptadine?
Posted by Amigan on July 7, 2008, at 12:46:49
In reply to Re: Looking for a med with these specifications, posted by Sigismund on July 7, 2008, at 3:21:25
> I dunno anything about this, but what about cyproheptadine?
I have never tried it either, but i looked at its pharmacological profile and it looks like a perfect choise!
Posted by bleauberry on July 7, 2008, at 20:28:34
In reply to Looking for a med with these specifications, posted by Amigan on July 6, 2008, at 19:19:54
If the issue is sleep, then there are actually a lot of options to try within the med and herbal field.
You asked about mirtazapine. I was on it for a year and am familiar its dose range from 2.5mg to 15mg. As accurate as I can tell, the norepinephrine stuff starts to come into play at about 7.5mg. It really doesn't get strong on NE until above 15mg though. Anyway, I found doses in the 2.5mg to 7.5mg to be knockout punches for sleep without any NE effect.
Posted by Sigismund on July 7, 2008, at 21:16:04
In reply to Looking for a med with these specifications, posted by Amigan on July 6, 2008, at 19:19:54
My problem with mirtazepine (7.5mg) was that the effect lasted most of the next day.
Other than that it felt great for deepening sleep.
Cypro shouldn't last through the next day if the half life (4 hours?) means anything, but it does with me, and I preferred mirtazepine.
I wonder if Linkadge was talking about the herb feverfew as being an antagonist of some of those serotonin receptor subtypes?
Posted by Amigan on July 12, 2008, at 2:17:14
In reply to Re: Looking for a med with these specifications, posted by bleauberry on July 7, 2008, at 20:28:34
Hi!
> If the issue is sleep, then there are actually a lot of options to try within the med and herbal field.
No. I need a real sedative that will knock me down. Herbs like passiflora and valeriana will not do that.
> You asked about mirtazapine. I was on it for a year and am familiar its dose range from 2.5mg to 15mg. As accurate as I can tell, the norepinephrine stuff starts to come into play at about 7.5mg. It really doesn't get strong on NE until above 15mg though. Anyway, I found doses in the 2.5mg to 7.5mg to be knockout punches for sleep without any NE effect.
Ok. Mirtazapine might be my only choice afterall, because i can't find cyproheptadine where i live. :-(
I have tried Mianserin in the past and it was effective for me. So, Mirtazapine should be effective as well, as it was manufactured to replace Miamserin in the market.
Posted by cumulative on July 17, 2008, at 18:23:05
In reply to Re: Looking for a med with these specifications » bleauberry, posted by Amigan on July 12, 2008, at 2:17:14
Where do you live? Cyproheptadine is OTC in Canada and is cheaply available by mail-order from respectable Canadian pharmacies (not more shifty pharmacies) to the United States and many other countries. Ahem.
Posted by Amigan on July 18, 2008, at 13:03:30
In reply to Re: Looking for a med with these specifications, posted by cumulative on July 17, 2008, at 18:23:05
I live in europe. It's not convinient for me to order meds from canada due to high post expenses and delays. I will stick to Remeron or try to find cyproheptadine from inside the EU. No big deal really.
This is the end of the thread.
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