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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by herpills on December 4, 2011, at 13:38:19
Does anyone have experience with this supplement as a substitute to Deplin?
Posted by Tauzin on December 9, 2011, at 20:43:24
In reply to L-methylfolate by Metabolic Maintenance 10mg, posted by herpills on December 4, 2011, at 13:38:19
I looked into this product also and found that it is from an unstable source of L-methylfolate and by the time you take it, it will be similar to taking a sugar pill. I found Metafolin as a supplement on the internet, but it is in doses of .4 and .8mg. I'm taking 15mg of Deplin and it would be way too expensive to take that many supplements. Good new is that there is now a generic Deplin and my co-pay was $15 last time I filled it - way cheaper than any over the counter option I've found.
Good luck!
Posted by herpills on December 10, 2011, at 21:44:14
In reply to Re: L-methylfolate by Metabolic Maintenance 10mg, posted by Tauzin on December 9, 2011, at 20:43:24
> I looked into this product also and found that it is from an unstable source of L-methylfolate and by the time you take it, it will be similar to taking a sugar pill. I found Metafolin as a supplement on the internet, but it is in doses of .4 and .8mg. I'm taking 15mg of Deplin and it would be way too expensive to take that many supplements. Good new is that there is now a generic Deplin and my co-pay was $15 last time I filled it - way cheaper than any over the counter option I've found.
>
> Good luck!Thank you for the response. Could you explain a little more how you came to the conclusion that this product is not a good form of methylfolate? I also found other supplements but the highest dose was 1mg. I don't have insurance so even generic Deplin can be expensive, and also a lot of insurance won't cover it anyway.
Posted by DavidR11 on December 12, 2011, at 0:27:19
In reply to Re: L-methylfolate by Metabolic Maintenance 10mg » Tauzin, posted by herpills on December 10, 2011, at 21:44:14
I work with Deplin and may add some information as well. First, the FDA requires that anything over 1mg of L-methylfolate be in a prescription form ONLY. Second, if you find a "generic" please make sure it is AB rated, in other words, the three or four generics to Deplin have not proven to be equal or make no claims to be. This is what AB rated or Orange book rated means. The generics contain folate from China (see their inserts) and does not meet guidelines in the U.S. The Deplin website provides information for those that have no insurance and I believe it is 48 dollars for 30 pills (15mg and scored). Most if not all "generics" out there do not have patient studies that show efficacy, so please be cautious when trying to find a generic.
Posted by MaryEm on December 31, 2015, at 21:38:35
In reply to Re: L-methylfolate by Metabolic Maintenance 10mg, posted by DavidR11 on December 12, 2011, at 0:27:19
I take Deplin as I have the MTHFR variant from both parents. I switched to Metabolic Maintenance L-methylfolate and it nearly killed me by not working at all. I asked if it was the same as Deplin generic and they said yes. It isn't. By the end of the first month I couldn't catch my breath and was extremely asthmatic. After going back on the Deplin generic, after about two weeks, I could breathe almost normally again. The Metabolic Maintenance is garbage and is absolutely NOT the same thing as Deplin L-methylfolate.
Posted by SLS on January 1, 2016, at 8:09:35
In reply to Re: L-methylfolate by Metabolic Maintenance 10mg » DavidR11, posted by MaryEm on December 31, 2015, at 21:38:35
Hi MaryEm.
Thanks for posting your observations. I hope it's smooth sailing for you from now on.
- Scott
Posted by MaryEm on January 1, 2016, at 17:04:44
In reply to Re: L-methylfolate by Metabolic Maintenance 10mg » MaryEm, posted by SLS on January 1, 2016, at 8:09:35
Thanks so much! I just found that I can buy Deplin from Canada for a tenth of what I've been paying, so that is good news! Now, I just hope my doctor will fax them the prescription.
Posted by Larry Hoover on January 6, 2016, at 16:56:07
In reply to Re: L-methylfolate by Metabolic Maintenance 10mg » SLS, posted by MaryEm on January 1, 2016, at 17:04:44
The currency exchange rate is very favourable right now, also. At the moment, one US$ is worth $1.41 Canadian.
Lar
Posted by MaryEm on January 6, 2016, at 22:22:46
In reply to Re: L-methylfolate by Metabolic Maintenance 10mg » MaryEm, posted by Larry Hoover on January 6, 2016, at 16:56:07
CanadaDrugStop let me down. They would not accept the comparison to Samsclub pharmacy, so they wanted about $425+ for 90 of the 15mg, so I'm looking into the Deplin plan at their site. Thanks for mentioning that Deplin will help with costs. My only other alternative is to see if I can get it from an Intertribal Clinic and I don't know if they even would carry it. Stock is limited and I wouldn't want to use it unless desperate.
I'm just glad to find out what has been wrong with me for so long. I finally got the genetic tests and I have all the bad variants for MTHFR from both parents, as I mentioned. I had already talked to my doctor about the issue prior to that since I had high homocysteine levels and abnormal RDW for 20 years. I researched it and brought the info to my PCP. So, my family doctor prescribed compounded methylcobalamin and L-methylfolate. I did, however, mention that my great-grandmother died of pernicious anemia, so there were three pieces of evidence prior to the genetic tests.
I buy liquid B-complex from the feed store and use it too, but not too frequently, about 3cc per month. It was the slightest amount of that which made my brain feel like it was flooded with white light. It was like I woke up from sleeping for many years. My doctors know about it and no one has objected when I tell them. I got the idea from a bodybuilders forum and from reading how one could definitively diagnose B deficiency by injecting a little. It only took about 1/10 of a ml of B-complex and it was like a miracle. It was like being cured of dementia in 2 seconds.
Just a note: My parents started taking me to psychiatrists by the time I was 14. To think I couldn't make the proper brain chemicals! Now, my son and his wife are having my granddaughter evaluated for psychiatric drugs and won't pay any attention to me when I tell them she could have the mutation that causes a serious vitamin deficiency and subsequent volatility.
It isn't just depression, it also causes one's cartilage to go away if there is a B12 problem because of the immature megaloblastic red cells not carrying oxygen and nutrition into the tiniest capillaries. The shortness of breath and asthma-like symptoms were the worst! But degenerative disk disease is also a result. I've had 3 spine fusions and a hip replacement by now that could have been avoided had this been detected a long time ago. My great-grandmother died at 23 of pernicious anemia. I think it's the same thing as the MTHFR mutation or rather a related consequence of the same mutations.
Maybe she helped me from THE OTHER SIDE :) One never knows and I'm pretty psychic anyway :) Thank you all for listening.
This is the end of the thread.
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