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Dr. Bob is Robert Hsiung, MD,
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Posted by sregan on September 15, 2006, at 15:54:27
I'm waiting for results from 24-hour cortisol saliva test but am pretty sure I'm hyper. I've been able to take about 400mg licorice in the morning, have my symptoms (anxiety, etc) continue long after the usual 6pm and felt very good (normal) the next day.
I believe the licorice extends the cortisol late enough that the feedback HPA lowers levels on the next day. I was just wondering what the activity of the 11 beta-HSD enzyme was if anybody had any information on timeframes for the feedback mechanisms.
If one has a high cortisol profile I'm assuming there is something wrong with the HPA that has altered one's diurnal production. Wouldn't the feedback be near immediate once high cortisol is detected the 11 beta-hsd is released? Or is the next day theory plausible (I got the idea from reading Cpt. David Williams article about adrenal fatigue/cfs).
And how long would the licorice inhibit the 11 beta-hsd?
Shawn
Posted by sregan on September 15, 2006, at 20:15:51
In reply to Cortisol and Licorice and 11 beta-hsd, posted by sregan on September 15, 2006, at 15:54:27
Also conversely, if I take a substance that decreases cortisol will that not just signal the HPA that I need more cortisol? Then I end up needing to take thecortisol decreasing substance every day. Unless I can find something that also fixes whatever is wrong in my HPA or Hippocampus.
Perhaps the Acetyl-L-Carnitine has an advantage here. Or even mifepristone (RU-486) which is looking like a miracle drug for some people (see link).
http://news-service.stanford.edu/news/2000/november8/ru486-1108.html
Posted by tealady on September 30, 2006, at 3:34:39
In reply to Cortisol and Licorice and 11 beta-hsd, posted by sregan on September 15, 2006, at 15:54:27
Wouldn't the feedback be near immediate once high cortisol is detected the 11 beta-hsd is released?
The problem here is that the HPA axis is not stand alone in the body. .. even though differing medical professions treat it as so..
Cortisol itself is also heavily tied in with the immune system.. AND I think it gets highish when body is trying to cope with (defend/attack etc) an immune disease, especially, I suspect early on. I think, from memory, It's one of the body's way of fighting the attack.. so high cortisol in itself may be just what your body needs.. and it lowers itself when its fixed the problem..
Some folk try to reduce the cortisol..and end up with more serious problems.. which the body may have overcome by itself if they hadnt lowered the cortisol levels.. I think (not really sure of, but I think they mentioned that it immune sytem lectures!)
Anyway.. it's just another thought.
Cortisol is also reat for educing inflammation..so one's body would produce more of it if some imflammation is going on ..naturally if it's worjking right..for protection of self, to top parts of body /nerves etc being destroyed?The only other thing I can maybe say is I think You have the right idea re licorice keeping cortiol levels up.. I use it for that on occasion. It slows the breakdown (or loss) of cortisol..also keeps up estrogen I think too?.. but it lowers potassium, so long tem be careful with that one. (eat some bananas and switch to lite salt (half K) while on licorice maybe?)
Sorry no more help, but slightly elevated cortsol is not in itself a bad thing, and maybe just what one needs?
Cushings level is another matter if it stays up there of course.. then I'd be asking a doc :)
This is the end of the thread.
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