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Dr. Bob is Robert Hsiung, MD,
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Posted by bleauberry on December 29, 2018, at 8:34:29
So this is just armchair theory. Just thinking out loud....
I was studying up on CBD oil. I learned that the oil weakly binds to the CBD1 and CBD2 receptors. Those are attached to all sorts of stuff involving mood, temperature, immune system and the opioid system.
In that weak binding CBD oil acts as both an agonist and an antagonist. It is described as "brushing" the receptors, with the end result being that it causes an increase of natural opioid production similar to how Low Dose Naltrexone does, and also helps existing opioids and neurotransmitters as a weak agonist of them.
From a consensus point of view some of the primary benefits people claim from CBD oil are anti-anxiety, anti-insomnia, anti-pain and anti-depression.
So I couldn't help but wonder, what if we dosed something like Prozac so lightly that it just brushed the receptors? So that it could in a sense excite the neurons with a little extra serotonin but not flood them? To just lightly touch them and lightly block them at the same time? Instead of overwhelming with a totally unnatural flood?
Or any med. Lightly brush the receptors with a tiny bit of Zoloft, Zyprexa, whatever. To get some of their mechanism, but only some. A totally different approach.
Maybe my first lyme doc was onto something when he said he had patients doing well on 1mg of Lexapro....
Heck I remember he started me on Lexapro at just one drop, which was 1/10th of 1mg, and I actually felt it. I hated Lexapro and wanted nothing to do with it and had already been there done that, so eventually had to find another doc. But the point was, he had found super-light dosing of psychiatric meds to work better than conventional dosing.
Just thinking out loud....
Posted by linkadge on December 29, 2018, at 17:25:44
In reply to Maybe Doses are Too High?, posted by bleauberry on December 29, 2018, at 8:34:29
The thing with CBD is that it hits many receptors 'weakly' would could contribute to a synergistic effect (akin to hitting a tumor with weak radiation from different angles to create an amplified signal at the desired target).
CBD interacts with cb1,cb2,5-ht1a,adenosine reuptake, endocannabinoid metabolism, TRVP, GRP3, gaba-a...the list goes on.
I read an article recently on how CBD acts as a positive modulator of the gaba-a receptors. It binds to some unknown site of the gaba-a receptor, increasing the sensitivity of the receptor. This, according to the authors, is responsible for the anticonvulsant effect.
The TRVP receptors are also a novel, interesting target, as they have anticonvulsant, anti-anxiety activity and work to 'regulate' the opioid system.
The only thing I would say about low dose prozac, is that, with fewer targets (i.e. SSRIS) you may need higher doses to have an effect. If an agent has more than one target, its activity at each target may not need to be as strong. Such an effect may also reduce side effects, as you are not overwhelming any one neurotransmitter system.
But really, I have no idea.
Linkadge
This is the end of the thread.
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