Posted by linkadge on December 29, 2018, at 17:25:44
In reply to Maybe Doses are Too High?, posted by bleauberry on December 29, 2018, at 8:34:29
The thing with CBD is that it hits many receptors 'weakly' would could contribute to a synergistic effect (akin to hitting a tumor with weak radiation from different angles to create an amplified signal at the desired target).
CBD interacts with cb1,cb2,5-ht1a,adenosine reuptake, endocannabinoid metabolism, TRVP, GRP3, gaba-a...the list goes on.
I read an article recently on how CBD acts as a positive modulator of the gaba-a receptors. It binds to some unknown site of the gaba-a receptor, increasing the sensitivity of the receptor. This, according to the authors, is responsible for the anticonvulsant effect.
The TRVP receptors are also a novel, interesting target, as they have anticonvulsant, anti-anxiety activity and work to 'regulate' the opioid system.
The only thing I would say about low dose prozac, is that, with fewer targets (i.e. SSRIS) you may need higher doses to have an effect. If an agent has more than one target, its activity at each target may not need to be as strong. Such an effect may also reduce side effects, as you are not overwhelming any one neurotransmitter system.
But really, I have no idea.
Linkadge
poster:linkadge
thread:1102639
URL: http://www.dr-bob.org/babble/20181024/msgs/1102646.html