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Dr. Bob is Robert Hsiung, MD,
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Posted by brynb on July 22, 2013, at 13:05:19
and
http://now.msn.com/protein-receptor-crf1-identified-as-depression-molecule#scpshrjmd
Anyone have any thoughts on this?
Posted by Tomatheus on July 22, 2013, at 13:32:21
In reply to Trending...'Misery Molecule', posted by brynb on July 22, 2013, at 13:05:19
From the first article:
"She added that now they have worked out the structure of it and how it works it could open up potential to design drugs to control it."
Actually, pharmaceutical companies are already doing this. There are a few CRF1 receptor antagonist drugs in clinical development for depression, anxiety, and PTSD.
See:
http://www.neurotransmitter.net/newdrugs.htmlAnd scroll down to the information for ONO-2333Ms, CXB722, and GSK561679.
I also think that the lead paragraph of the first article was misleading ("Scientists have found the brain's 'misery molecule' believed to be responsible for all of our feelings of stress and anxiety."). It's my understanding that there are several molecules that are believed to play a role in feelings of stress, anxiety, and misery, which would mean that there can't just be one single molecule that controls for all of these things. A quote further down in the article even emphasizes that CRF1 is just one brain protein that plays a role in anxiety and depression, not the only such protein. To call CRF1 the one-and-only "misery molecule" is in my opinion flat-out wrong.
That more or less sums up my thoughts on what was written. Anyone agree, disagree, or have anything to add?
T.
Posted by brynb on July 22, 2013, at 13:39:21
In reply to Re: Trending...'Misery Molecule', posted by Tomatheus on July 22, 2013, at 13:32:21
Thanks for making those points, Tomatheus. Are you familiar with any of the CRF1 receptor antagonist drugs and any trials?
Two separate people emailed the articles to me this morning, lol.
Thanks,
b
Posted by linkadge on July 22, 2013, at 13:46:55
In reply to Trending...'Misery Molecule', posted by brynb on July 22, 2013, at 13:05:19
This is not really a new target. CRF1 receptors are modulated during postive response to a variety of AD treatment. Drugs like tianeptine, TCA's, mirtazpine and ECT have a more profound effect on the HPA axis and CRF1 receptors.
RU486 was a drug that was supposedly being 'fast tracked' for psychotic depression. This was over a decade ago. It acts directly on CRF receptors.
Linkadge
Posted by Tomatheus on July 22, 2013, at 14:24:54
In reply to Re: Trending...'Misery Molecule', posted by brynb on July 22, 2013, at 13:39:21
Hi Bryn,
Thank you for your reply. Unfortunately, I'm not too familiar with the details of the trials being done on CFR1 antagonists, but I did know that the trials were being done. I can say that the drugs that I mentioned from the neurotransmitter.net site are in Phase II clinical development, which means that the drugs have made it through the earliest (Phase I) studies but are still in the process of being evaluated for efficacy and tolerability. That pretty much sums up what I know about the investigational medications that target the CRF1 receptor. Maybe somebody else here will know more about them.
T.
Posted by Hugh on July 22, 2013, at 14:38:58
In reply to Trending...'Misery Molecule', posted by brynb on July 22, 2013, at 13:05:19
Mark George, who was the first to study TMS for depression, said he thought depression should be called "the depressions," because so many different things can cause it. It's my guess that when treatments for the misery molecule become available, many people will be helped, and many people won't. It's just one piece of the puzzle, but a very important piece.
Posted by Phillipa on July 22, 2013, at 15:55:57
In reply to Trending...'Misery Molecule', posted by brynb on July 22, 2013, at 13:05:19
I have to wonder if the microadenoma found twice on MRI of my brain could be responsible for my anxiety? Phillipa
Posted by linkadge on July 22, 2013, at 21:30:50
In reply to Re: Trending...'Misery Molecule', posted by Hugh on July 22, 2013, at 14:38:58
I think that CRH1 may be a viable target for stress induced mood disorders (or disorders with a high degree of anxiety). However, I just went through a bad episode over a year ago with zero anxiety - all apathy and low energy.
I think SJW works on CRH receptors to some extent.
Linkadge
Posted by Lamdage22 on July 30, 2013, at 14:51:07
In reply to Re: Trending...'Misery Molecule' » brynb, posted by Phillipa on July 22, 2013, at 15:55:57
All i can say is, if Pharma reads here. GO GO GO!
So much exiting stuff.. how long do you think nmda or crf1 drugs will reach the market?
Or anti-ceramide drugs. All that stuff.
How long you think?
This is the end of the thread.
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