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Re: Trending...'Misery Molecule'

Posted by Tomatheus on July 22, 2013, at 13:32:21

In reply to Trending...'Misery Molecule', posted by brynb on July 22, 2013, at 13:05:19

From the first article:

"She added that now they have worked out the structure of it and how it works it could open up potential to design drugs to control it."

Actually, pharmaceutical companies are already doing this. There are a few CRF1 receptor antagonist drugs in clinical development for depression, anxiety, and PTSD.

See:
http://www.neurotransmitter.net/newdrugs.html

And scroll down to the information for ONO-2333Ms, CXB722, and GSK561679.

I also think that the lead paragraph of the first article was misleading ("Scientists have found the brain's 'misery molecule' believed to be responsible for all of our feelings of stress and anxiety."). It's my understanding that there are several molecules that are believed to play a role in feelings of stress, anxiety, and misery, which would mean that there can't just be one single molecule that controls for all of these things. A quote further down in the article even emphasizes that CRF1 is just one brain protein that plays a role in anxiety and depression, not the only such protein. To call CRF1 the one-and-only "misery molecule" is in my opinion flat-out wrong.

That more or less sums up my thoughts on what was written. Anyone agree, disagree, or have anything to add?

T.


Conditions:
* chronic fatigue, hypersomnia, and related symptoms
* schizoaffective disorder

tomatheus.blogspot.com


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poster:Tomatheus thread:1047618
URL: http://www.dr-bob.org/babble/20130706/msgs/1047620.html