![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by metamorphosis on January 5, 2013, at 14:15:02
Okay, input would really help here.
This is day 8 and I am currently on 40mg of Parnate now. 20mg in the morning and the other 20mg early afternoon along with the Lamictal 300mg and klons.4mg.I am having some side effects that I expected but also one that I did not expect.
Last night I finally got about 6 hrs. sleep but I can tell it is not deep stage 3-4 sleep. I seem to be stuck in the lighter stages of sleep. I have not used any sleeping med. yet. My pdoc wants me to wait until I see him on the 10th. So, we can talk about all of the issues.
The sleep issue I expected as that is a big side effect of MAOI's.
Today, I woke up and took the morning dose, 20mgs. I have been moderately depressed today with anhedonia and dysphoria.
Again, I realize that this is also part of the MAOI rollercoaster ride.
I have also been trying to dose my klonopin at night for sleep.
But I have not been able to do this. After dosing my Parnate inevitably irritation becomes an issue and I take 2 mg of Klonopin. I also understand that the stimulating properties of Parnate is a common side-effect. I I do not know what I would do without having the Klonopin on hand to take the edge off. That would be rough going.
The side effect I did not expect was daily headaches. They are not migraines but just dull frontal region headaches. I have to take ibuprofen to relieve them. I have never had an issue with headaches.
The issue is that it isn't caused by hypertension. this morning I took my b.p. 3 times-128/80, 125/84, 118/99. So I am trying to fiqure this one out.
Is this a pretty common side-effect with normal b.p., that I did not know about?
There are three things that may be causing it. The combination of ongoing poor sleep. To much time spent in front of the computer and my coffee consumption with the Parnate. I want to slowly reduce my coffee consumption to two cups a day. But that is also very difficult with the fatigue of lack of sleep and the somnolence I feel a few hrs after my morning Parnate dose. I love coffee and have been drinking it for yrs. I'm sure part of this has to do with it's ant-depressant qualities.
I am hanging in there. Most of these side effects I can deal with, for now. I really don't want to stop the Parnate prematurely without a fair trail. Then later on down the line, think what if?
I am not even close to that point at this time. But any comments, advice, possible explanations for these non-hypertensive crises would be appreciate.
Sensitivity to the cold is another expected and tolerable side effect.
It is so frustrating when I do not have motivation to even make the necessary phone calls I need to make because I am feeling like crap and I just don't care.
I hope some of the worst side-effects subside. The depression with the anhedonia and dysphoria are very difficult to deal with. As are the daily headaches.
It is becoming a huge issue just to get up the motivation to take a shower and shave every 2-3 days! It really sucks and is disheartening!
Posted by baseball55 on January 5, 2013, at 19:33:24
In reply to Parnate thread/ dealing with side effects, posted by metamorphosis on January 5, 2013, at 14:15:02
Are the ahedonia and dysphoria side effects of parnate or just vestiges of depression that parnate hasn't yet quite reached?
My only side effects were dry mouth (still have it, but not so bad), very bad orthostatic hypotension (which resolved after several months) and terrible insomnia, for which I still take trazadone and xanax at night.
Headaches, chills, never heard of. But everyone's different. But I do wonder whether the mood effects are due to parnate or are simply more noticeable aspects of depression which parnate is failing to treat.
Posted by sigismund on January 5, 2013, at 19:44:14
In reply to Re: Parnate thread/ dealing with side effects, posted by baseball55 on January 5, 2013, at 19:33:24
Baseball85 is not the same as baseball55.
I thought something didn't make sense.
Posted by Phillipa on January 5, 2013, at 22:41:38
In reply to Re: Parnate thread/ dealing with side effects » baseball55, posted by sigismund on January 5, 2013, at 19:44:14
Sigi who is Baseball 55? And where have you been? PJ
Posted by metamorphosis on January 6, 2013, at 14:31:46
In reply to Re: Parnate thread/ dealing with side effects, posted by baseball55 on January 5, 2013, at 19:33:24
> Are the ahedonia and dysphoria side effects of parnate or just vestiges of depression that parnate hasn't yet quite reached?
>
> My only side effects were dry mouth (still have it, but not so bad), very bad orthostatic hypotension (which resolved after several months) and terrible insomnia, for which I still take trazadone and xanax at night.
>
> Headaches, chills, never heard of. But everyone's different. But I do wonder whether the mood effects are due to parnate or are simply more noticeable aspects of depression which parnate is failing to treat.Since starting Parnate, I am having more bouts of depressive symptoms. I haven't had anhedonia or dysphoria like yesterday for over 6 months. Since starting the Parnate 10 days ago, it has resurfaced. Not everyday, but the strong atypical depression is definitely a factor since starting. I slept around 14 hrs., from yesterday until noon today. Which hasn't happened for a few months. I still woke up feeling tired. It may also have to do with the lack of sleep I have been suffering since starting the med.
But I cannot live like that. Not only does it increase my depression. It makes my anxiety ramp way up. Plus my daily living cannot be that compromised. Tomorrow, I have a very important appt. at 7:15 am. That I cannot miss! I am actually considering staying up for the night because I will be having to catch the bus at 5:30-or 6 am! And I cannot oversleep in a coma like state.
So, I naturally question what effects the Parnate is having on the triple monoamines along with the adaptation of the brain. What dose exactly cause this. Yesterday was a pretty hard day mentally. I think I have narrowed down the possibility of the non-heypertesnsive headaches. It is a common complaint with those taking methyl-folate (Deplin). So, I am laying of the deplin for a few days to see if that is the problem.
Also, I read somewhere that Lamictal can increase the potency of Parnate. I am not sure if it the action on the actoin on the same enzymes or just the synergistic effects of the two meds. together? I was to lethargic and depressed to look into it further, yesterday.
So, what are some of the common side-effects and uncommon side-effects for members on/or were Parnate users?
Did it cause an increase in depressive symptoms initially?
What was the most common reason you stopped Parnate?
Those of you still on it.
How long has it been?
How are you doing on it?
What other meds., do you use daily?I just need some reassurance at this point. It is one thing to read the expected side-effects. It's another to actually experience them?
I do see my pdoc this week. I want to add modafinil and either trazodone or doxepin for sleep. I like trazodone for it's lack of anti-cholinergic properties,along with 5-HT2A antagonism. The trazodone possibly increasing my deep sleep cycle. I also like trazodone for it's 5-HT2A antagonism. Also,the antihistamine activity is relatively weak and probably clinically insignificant from what I know.
I think the modafinil will help my motivation as it has before.
I do not think it is contra-indicated with Parnate but am not sure?
I hope not. The only reason why, I would reason is if my b.p. is staying at a relatively high level. Which isn't the caseI am hoping my pdoc. will be open to these meds.
suggestions.So, any responses are appreciated and will help me in one way or another.
Thanks, Chris
Posted by baseball55 on January 6, 2013, at 18:50:52
In reply to Re: Parnate thread/ dealing with side effects, posted by metamorphosis on January 6, 2013, at 14:31:46
For me, parnate had a very quick and positive effect on my depression, which had been severe (I had barely gotten out of bed for a month). But I had bouts of bad depression after, even with parnate. I still take it and it's had no negative effects on me, but I'm thinking about going off it because I'm not sure it any longer has positive effects. I take it with lamictal, since a year ago and have been very stable this past year.
Maybe it's not effective for you. I don't know how long others have waited to get an effect. For me it worked within a couple of days.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.