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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by jono_in_adelaide on September 26, 2012, at 19:37:19
Anybody had any significant effect from this stuff.... I take a multi with 800ug of folic acid, so I cant be deficient, but I have wondered if it might be worth trying the activated form
I tried taking 5000ug of folic acid per day a while ago and it seemed to have no efect what so ever.
Posted by herpills on September 26, 2012, at 19:44:09
In reply to Metafolin/Deplin/l-methylfolate, posted by jono_in_adelaide on September 26, 2012, at 19:37:19
I'm currently taking 7.5mg of Deplin. I find it mildly activating. I used to take it with Pristiq, but went off that but still take the Deplin. You could always buy some methylfolate over the counter in 1mg dose and experiment before investing in a bottle of Deplin. herpills
Posted by Tomatheus on September 26, 2012, at 19:55:20
In reply to Metafolin/Deplin/l-methylfolate, posted by jono_in_adelaide on September 26, 2012, at 19:37:19
Jono_in_Adelaide,
I've taken l-methylfolate, with doses ranging from 800 mcg to 2.4 mg. As far as positive effects are concerned, I noticed a mild energizing effect on the first day that I took the supplement, with no positive benefits after that. I did notice an increase in my auditory pseudohallucinations when I tried 2.4 mg, but it would be my guess that this isn't something that should be a problem in individuals who don't already experience auditory pseudohallucinations.
I think that the l-methylfolate is something that's worth trying. It affected me differently than folic acid affects me, and even though positive effects from l-methylfolate were transient for me, the nutrient might help some individuals in the long run.
That sums up my thoughts on l-methylfolate. Please let me know if you have any questions concerning what I've written.
Tomatheus
Posted by jono_in_adelaide on September 26, 2012, at 20:13:53
In reply to Re: Metafolin/Deplin/l-methylfolate, posted by Tomatheus on September 26, 2012, at 19:55:20
Thanks, deplin isnt on the market in Australia, so I'll have to buy the OTC stauu and try it.... the OTC pills are only 800mcg, so I'll need to several each day
Posted by phillipa on September 26, 2012, at 20:49:12
In reply to Re: Metafolin/Deplin/l-methylfolate, posted by jono_in_adelaide on September 26, 2012, at 20:13:53
If you go to the Deplin site it compares the Deplin and how many pills you need to compare dose. I did take a month of it noticed nothing at all good or bad. So stopped it. I think it was expensive. Phillipa
Posted by herpills on September 26, 2012, at 22:47:42
In reply to Re: Metafolin/Deplin/l-methylfolate » jono_in_adelaide, posted by phillipa on September 26, 2012, at 20:49:12
> If you go to the Deplin site it compares the Deplin and how many pills you need to compare dose. I did take a month of it noticed nothing at all good or bad. So stopped it. I think it was expensive. Phillipa
It's not expensive now, I pay $144 for 6 months worth so $24/month thats with no insurance. herpills
Posted by bleauberry on September 27, 2012, at 9:09:25
In reply to Metafolin/Deplin/l-methylfolate, posted by jono_in_adelaide on September 26, 2012, at 19:37:19
You have to try a variety of the B's and related vitamins, including the common forms, the active forms, and combination forms. It's the only way to weed out the losers and identify the winners, both of which will be very different from one person to the next. In almost every case, singular vitamins aren't going to get the job done, in my opinion.
I take two different brands of vitamins because both have combinations of the common forms and active forms of all the various B's. Just as important are the carrier molecules or cofactors...in this case they are all the good stuff such as picolinate, methyl, glycinate. None of the worthless citric crap, oxide junk, and other common junk.
I've tried all of the ingredients of these vitamins separately over the years, and none were helpful, some were problematic. However when combined in a high quality product, I can actually feel benefit. So it's not any single vitamin such as folic acid or B12 or B6, but rather, the synergy of them all, including portions of their active forms, and the gold standard carrier molecules.
Something else to keep in mind is what my doctor explained to me. That is, health doses are far lower than therapeutic doses. For example, if 400 units of folic acid is considered 100% of daily requirement, that is what it takes to keep the body alive, not the amount it takes to heal something. When it comes to folate specifically, information gathered from lyme circles and psychiatry circles, the necessary doses are in the 1000s, not the 100s, such as, for example, 5000mg a day.
For someone to say they tried a double dose of B12 or folate or whatever, and didn't notice anything after a few days, is completely insignificant and meaningless. They barely even scratched the surface on several regards.
Posted by Hugh on September 27, 2012, at 13:32:23
In reply to Metafolin/Deplin/l-methylfolate, posted by jono_in_adelaide on September 26, 2012, at 19:37:19
I've taken Solgar brand folate (metfolin) and it decreases my libido just like most of the antidepressants I've tried, so I know it's doing something. (5-HTP is another supplement that does this to me.) Regular folic acid, which I've taken on and off for fifteen years, never had this effect on me. A lot of people have trouble converting B-vitamins into their active forms, so in addition to l-methylfolate, some other activated B-vitamins worth trying are P5P (B6), methylcobalamin (B12) and benfotiamine (B1). The benfotiamine was way too stimulating for me, but I'm hypersensitive to stimulants.
Posted by jono_in_adelaide on September 27, 2012, at 21:10:16
In reply to Re: Metafolin/Deplin/l-methylfolate, posted by Hugh on September 27, 2012, at 13:32:23
I guess I'll buy a bottle of the Solgar brand and see if it helps - all i have to lose is 12 dollars!
Posted by ChicagoKat on September 29, 2012, at 15:39:57
In reply to Re: Metafolin/Deplin/l-methylfolate, posted by jono_in_adelaide on September 27, 2012, at 21:10:16
> I guess I'll buy a bottle of the Solgar brand and see if it helps - all i have to lose is 12 dollars!
Just FYI re all y'all's talk of the 3 different agents, I was prescribed Deplin and it did Jack sh*t for me. Take care!
Kat
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