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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Vincent_Qc on March 18, 2012, at 18:58:22
Hi everoyne, maybe some peoples here can help me about the clonidine action for anxiety who seem related to a high noradrenaline\adrenaline level.
I have normal-low blood pressure at home around 105-110 on 65-70 and its higher out of the house. Have dizziness and fast pulse ar rest around 90-120 and always speed up to the 140 and more pulse rate with minimal exercise like taking a shower...also have pounding heart beat all the time even when my blood pressure is low.
I start having chronic chest pain with numbness of the left arm who seem to radiate in the neck veins and also always have headache...
Im on a low dose of Inderal but cant take more than 10mg day since its lowering too much my blood pressure and give more anxiety symptoms. It was working great in the past to reduce the fast heart rate but now its not effective..
So I want to know if I can take the Inderal in the morning for the tachycardia and take small dose of Clonidine at the same time? If so, what is the best dose for my type of anxiety, a dose who will just reduce the adrenaline\noradrenaline without lowering my blood pressure?
I have some 0.1mg pills but never try it properly... Does the Clonidine can help with the fast heart beat, the pounding heart and the chest pain...? Can it help also to improve my headache pain?
I also have more adrenaline\noradrenaline surge at night and have insomnia...take forever to fall asleep and wake up cover of sweat with fast heart rate most of the time...
Also I dont understand why its possible to have lower blood pressure with high adrenaline? Also I dont understand why its possible to feel so tired when noradrenaline or adrenaline is suppose to keep you awake and give energy...my energy level is near 0...cant barely move from my bed to the couch and always feel like I need to sleep and if I go in bed I cant...
The small 2 mg dose of Remeron I take for my insomnia cant do all of this no? Will have to ask about somethings else to help me to sleep since I already take high dose of clonazepam 8 mg day and some xanax as needed but never more than 0.25 mg a day... Maybe will ask for a very low dose of Trimipramine, who seem to work on low dose like 2 mg for the insomnia without affecting too much the NE...
Well if someone here is used to the clonidine and the correct dosage to use for the type of anxiety I have, I will be very happy about getting advises...
Thanks!
Posted by phidippus on March 18, 2012, at 20:05:01
In reply to clonidine in low dose for somatic anxiety?, posted by Vincent_Qc on March 18, 2012, at 18:58:22
I would switch to Prazosin. Not only will it treat your BP issues, but help a lot more with your anxiety issues.
Eric
Posted by Vincent_Qc on March 18, 2012, at 20:50:46
In reply to Re: clonidine in low dose for somatic anxiety? » Vincent_Qc, posted by phidippus on March 18, 2012, at 20:05:01
> I would switch to Prazosin. Not only will it treat your BP issues, but help a lot more with your anxiety issues.
>
> EricHi Eric, will ask my Doc about it...I think that prazosin can lead to tachycardia and faintness no? I already feel dizzy when I get up and have reflex tachycardia when I standing...thats why I write that I cant take higher dose of inderal since I use it to reduce the heart rate and not for lowering my blood pressure...
Since having a lower blood pressure increase my anxiety much more than high blood pressure, I may think it will not be suitable for me...maybe a change to another beta-blocker will be more effective even if I try almost all of them and the Inderal was the only one to lower my blood pressure...
Anyway thanks for your advises!
Bye, vincent
Posted by phidippus on March 18, 2012, at 21:08:00
In reply to Re: clonidine in low dose for somatic anxiety?, posted by Vincent_Qc on March 18, 2012, at 20:50:46
Prazosin is an alpha blocker and will lower your heart rate.
Another one to try is Mexeletine.
Eric
Posted by Phillipa on March 18, 2012, at 22:01:13
In reply to Re: clonidine in low dose for somatic anxiety? » Vincent_Qc, posted by phidippus on March 18, 2012, at 21:08:00
Will write later. Working too much
Posted by sigismund on March 19, 2012, at 2:35:52
In reply to Re: clonidine in low dose for somatic anxiety?, posted by Vincent_Qc on March 18, 2012, at 20:50:46
>I think that prazosin can lead to tachycardia and faintness no?
Faintness to begin, yes, although it it didn't happen to me (took it at night).
No increase in heart rate.
I take 2mg a day with no problems.
Posted by SLS on March 19, 2012, at 7:11:53
In reply to Re: clonidine in low dose for somatic anxiety? » Vincent_Qc, posted by phidippus on March 18, 2012, at 21:08:00
> Prazosin is an alpha blocker and will lower your heart rate.
>
> Another one to try is Mexeletine.That is an interesting choice. If I recall, mexelitine has been looked at to treat difficult cases of bipolar disorder.
- Scott
Posted by SLS on March 19, 2012, at 7:21:32
In reply to clonidine in low dose for somatic anxiety?, posted by Vincent_Qc on March 18, 2012, at 18:58:22
Prazosin is a sympatholytic, but I don't know how it compares to clonidine in this regard. They have entirely different mechanisms of action.
What about propranalol? Clonidine is much more likely to produce depression than propranolol.
- Scott
Posted by Vincent_QC on March 20, 2012, at 7:56:24
In reply to Re: clonidine in low dose for somatic anxiety? » Vincent_Qc, posted by phidippus on March 18, 2012, at 21:08:00
> Prazosin is an alpha blocker and will lower your heart rate.
>
> Another one to try is Mexeletine.
>
> EricThanks Eric, will ask my Doc about the Prazosin...
Posted by Vincent_QC on March 20, 2012, at 7:57:26
In reply to Re: clonidine in low dose for somatic anxiety? » Vincent_Qc, posted by sigismund on March 19, 2012, at 2:35:52
> >I think that prazosin can lead to tachycardia and faintness no?
>
> Faintness to begin, yes, although it it didn't happen to me (took it at night).
>
> No increase in heart rate.
>
> I take 2mg a day with no problems.
>
>Thanks ;-)
Posted by Vincent_QC on March 20, 2012, at 8:23:12
In reply to Re: clonidine in low dose for somatic anxiety? » Vincent_Qc, posted by SLS on March 19, 2012, at 7:21:32
> Prazosin is a sympatholytic, but I don't know how it compares to clonidine in this regard. They have entirely different mechanisms of action.
>
> What about propranalol? Clonidine is much more likely to produce depression than propranolol.
>
>
> - ScottHi scott, hummm I already take propanolol (Inderal) and can't take more than 10 mg day of it cause it's lowering too much my blood pressure...give to me more insomnia even at that low dose and also make me very tired....like all the others beta-blockers but the Inderal have a flexibility in the doses who is bigger than the other ones, I mean that you can take 5 mg and feel it's effect to decrease the heart rate or the sweating without affecting the blood pressure and at 40 mg or 80 mg it can be effective to lower the blood pressure...but on me it's seem that I have weak beta-receptors and alpha receptors as well since I always react badly to meds who affect those receptors OR had problems like severe orthostatic hypotension on 60 mg of Nardil even with the use of florinef... and had hypertensive crisis without foods interraction on the Parnate who almost kill me even if I always had on me some nifepidine pills in case of emergency... and I always react badly to all the TCA's...tachycardia mainly... with another one beta-blocker like the bisoprolol, the effective dose is 10 mg to lower the blood pressure, so you don't have the same flexibility in the doses and for the bisoprolol on me only 1 mg will put me in the low blood pressure category so I can't take it...
The clonidine is interresting cause I can use it for the insomnia at the same time that's why I ask about it use here... I know it's not very good to lower the blood pressure, but that's not the effect I want, I need something who will stop the adrenaline/noradrenaline production and something who will reduce my heart rate...
The Prazosin seem too powerfull, also I wonder if I will have the same kind of reaction on it than on drugs who are also alpha 1 antagonist like the Seroquel for example? Always had worse tachycardia from all the atypical antipsychotics meds especially the ones who touch more the alpha adrenergic receptors.... I don't think my Doc will agree about taking it since i'm on the low blood pressure side at home, even at night when I wake up in a panic attack mood, sweating from everywhere on my body, my blood pressure is normal to low...
Maybe you can help me to understand some tests results from last year, I had the same kind of anxiety but not as worse with mainly tachycardia in the morning, now it's all the time? I had a 24 hours urinary test for the cortisol,adrenaline, noradrenaline and dopamine... My cortisol level was low around 60 and the normal range is between 40 and 600 or more I don't really remember... the dopamine was at 3000 and the maximum range is around 4800... the adrenaline level was undectable, mean less than 25 and the maximum range is around 150... the noradrenaline was at 124 with a range from 80-400 I think...
I don'T know how it's possible to have low adrenaline and noradrenaline level if I have so many cardiovascular symptoms from the anxiety??? Of course my Doc say I had normal results... and the cortisol from the blood tests was normal also but on the low side...but no addison disease or no cancer on the adrenal glands as well and normal supression test for the cortisol...
Anyway thanks for your answer ;-)
Oh, for the depression I don't really care, already on high benzo doses who can also induce depression... and to be honnest I think it's better to feel depress (not suicidal anyway) than having cardiovascular symptoms related to the anxiety like I have all the time...
Just learn that the Zolpidem is approved in the Canada since last year... 10 mg sublinguial dose... is it a good med for the insomnia? I try in the past the Zopiclone but it was doing nothing on me even at 15 mg...
This is the end of the thread.
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