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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by jparsell82 on February 16, 2005, at 19:18:06
Just now starting Adderall(XR) with my daily Klonopin. I've heard of NMDA antagonists helping and I remember reading something about Alka-seltzer awhile back that Ames Sans Vie posted. Anyone have any simple suggestions? Recommended brand of dextromethorphan? Thanks,
Josh
Posted by dondon on February 16, 2005, at 21:26:56
In reply to Suggestions for combating amphetamine tolerance?, posted by jparsell82 on February 16, 2005, at 19:18:06
taking a whole bottle of couph serup(dextromethorphan) will kill you. But lower doses fry your brain like an egg and get you high. "high off couph serup" nmda antagonists
Posted by Caslon540 on February 17, 2005, at 2:24:35
In reply to Re: Suggestions for combating amphetamine tolerance?, posted by dondon on February 16, 2005, at 21:26:56
> taking a whole bottle of couph serup(dextromethorphan) will kill you. But lower doses fry your brain like an egg and get you high. "high off couph serup" nmda antagonists
Scare-mongering.
More later, on this and the original poster's question.
Posted by Caslon540 on February 17, 2005, at 4:33:26
In reply to Re: Suggestions for combating amphetamine tolerance?, posted by dondon on February 16, 2005, at 21:26:56
I take 400 mg of magnesium taurate (200 in the morning, 200 in the afternoon) to help keep my adderall tolerance down. As for DXM, which I used before the magnesium, I like Delsym because it's like a 12-hour formula or something. I wish there was a way to get extended release magnesium tablets...
> taking a whole bottle of couph serup(dextromethorphan) will kill you.
The above statement is false. Now, this does not mean that it would be correct to say, "taking a whole bottle of cough syrup will NOT kill you," either, because it's simply not that black or white. Let me make this clear, just for anyone who reads this that is considering the recreational DXM-via-cough-syrup dissociative/psychedelic experience: you ARE LIKELY TO DIE a slow, painful death if you use syrup recreationally that has acetaminophen in it. Use a syrup in which dextromethorphan is the ONLY active ingredient. DO YOUR RESEARCH before you do any drug. For DXM, start with this: http://www.third-plateau.org/dangers/
> But lower doses fry your brain like an egg and get you high. "high off couph serup" nmda antagonists
This statement is also false. If it were true, every person that uses cough syrup as per directions on the bottle would get high and have what I'm assuming you're referring to as very severe brain damage.
From the DXM FAQ (http://www.third-plateau.org/faq/dxm_faq.shtml):
"This brings me to the most relevant new information about DXM: Olney's findings of NMDA Antagonist Neurotoxicity (NAN). There is great debate right now whether NAN is relevant at recreational doses or not. In animals, the dosage required to induce NAN is far in excess of the anaesthetic dose, and humans typically take sub-anaesthetic doses of dissociatives. On the other hand, there may be danger with long-term use at considerably lower dosages that the animal models do not show.
"The data from human experiences are hard to interpret. Many heavy PCP users suffer obvious cognitive and motor impairment; however, PCP has neurotoxic effects (in particular in the cerebellum) not shared by other dissociatives including DXM or ketamine. Ketamine is probably a better approximation of DXM, but very few people have done large amounts of ketamine for long periods of time. A notable exception is John Lilly, who is a bit of a nut, but was probably a bit of a nut before doing ketamine, and (at least the last time I checked) he doesn't seem to suffer from cognitive impairment.
"There are a few DXM users who have suffered long-term consequences. Out of approximately five hundred current and former DXM users I have heard from, three have suffered lasting cognitive impairment. Additionally, there is one published paper on cognitive impairment from chronic DXM use, although the author suggests an underlying temporal lobe seizure disorder."
Posted by Caslon540 on February 17, 2005, at 4:44:18
In reply to Re: Suggestions for combating amphetamine tolerance?, posted by Caslon540 on February 17, 2005, at 4:33:26
> I take 400 mg of magnesium taurate (200 in the morning, 200 in the afternoon) to help keep my adderall tolerance down. As for DXM, which I used before the magnesium, I like Delsym because it's like a 12-hour formula or something. I wish there was a way to get extended release magnesium tablets...
Oh, I need to clarify: I stopped using Delsym when I started using magnesium. Although I would guess (wildly) that DXM is a more potent NMDA antagonist than magnesium, I decided to stick with magnesium instead of DXM because I can tolerate pills better on a daily basis than sickeningly sweet cough syrup.
I think I was taking 4 teaspoons of the Delsym when I used it.
Posted by jparsell82 on February 18, 2005, at 12:10:59
In reply to Re: Suggestions for combating amphetamine tolerance?, posted by Caslon540 on February 17, 2005, at 4:44:18
> > I take 400 mg of magnesium taurate (200 in the morning, 200 in the afternoon) to help keep my adderall tolerance down. As for DXM, which I used before the magnesium, I like Delsym because it's like a 12-hour formula or something. I wish there was a way to get extended release magnesium tablets...
>
> Oh, I need to clarify: I stopped using Delsym when I started using magnesium. Although I would guess (wildly) that DXM is a more potent NMDA antagonist than magnesium, I decided to stick with magnesium instead of DXM because I can tolerate pills better on a daily basis than sickeningly sweet cough syrup.
>
> I think I was taking 4 teaspoons of the Delsym when I used it.Thanks for the information. Yeah, I also don't care for the syrup. I was wondering if there was a decently priced extended release capsule or something. I think Ames Sans Vie mentioned he took Dexalone??? I'll have to run a search on it. Is magnesium taurate better absorbed? I have magnesium citrate at home I take occasionally. I also thought about Memantine... but I don't know if my doctor will prescribe that. Maybe the Memantine could also help out with the Klonopin memory problems I sometimes have.
Josh
Posted by Cairo on February 19, 2005, at 8:50:04
In reply to Re: Suggestions for combating amphetamine tolerance?, posted by Caslon540 on February 17, 2005, at 4:33:26
>> I wish there was a way to get extended release magnesium tablets...
There is something called Slow Mag which contains 212 mg of magnesium chloride in an enteric coated tablet.
Cairo
Posted by CareBear04 on February 19, 2005, at 16:42:15
In reply to Suggestions for combating amphetamine tolerance?, posted by jparsell82 on February 16, 2005, at 19:18:06
hi, i'd worked up a tolerance to 50-60mg of adderall. while in the hospital for med reasons the past few days, they didn't give me any stimulants; i didn't even have coffee. just a few days off helped a lot. of course, since i was just lying in bed, i could afford to lack energy. but i guess it is true that the best way to avoid tolerance is to take med vacations.
Posted by Caslon540 on February 20, 2005, at 13:19:23
In reply to Re: Suggestions for combating amphetamine tolerance? » Caslon540, posted by jparsell82 on February 18, 2005, at 12:10:59
> Is magnesium taurate better absorbed?
Not sure, I totally bought into someone's testimonial without researching it, hahaha. "Doh!"
I really need to look that up...
Posted by Caslon540 on February 20, 2005, at 13:21:17
In reply to Re: Suggestions for combating amphetamine toleranc » Caslon540, posted by Cairo on February 19, 2005, at 8:50:04
> There is something called Slow Mag which contains 212 mg of magnesium chloride in an enteric coated tablet.
Thanks, I'll keep that in mind :)
Posted by Caslon540 on February 20, 2005, at 13:33:45
In reply to Re: Suggestions for combating amphetamine toleranc » jparsell82, posted by CareBear04 on February 19, 2005, at 16:42:15
> hi, i'd worked up a tolerance to 50-60mg of adderall. while in the hospital for med reasons the past few days, they didn't give me any stimulants; i didn't even have coffee. just a few days off helped a lot. of course, since i was just lying in bed, i could afford to lack energy. but i guess it is true that the best way to avoid tolerance is to take med vacations.
I *wish* med vacations worked for me. :/
This is the end of the thread.
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