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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by mmcconathy on October 12, 2004, at 19:57:58
I know there's lots of benzo's. And dont forget about the barbiturates.
I am just curious, because i took Amytal 50mg, and it was pretty sedating.
Thanks.....
Matt
Posted by utopizen on October 12, 2004, at 21:58:02
In reply to What is the most potent sedative/tranquilizer?, posted by mmcconathy on October 12, 2004, at 19:57:58
> I know there's lots of benzo's. And dont forget about the barbiturates.
>
> I am just curious, because i took Amytal 50mg, and it was pretty sedating.
>
> Thanks.....
>
> MattBarbituates are not as effective in reducing anxiety as benzos. Benzos are more effective at doing this, and also don't make you drowsy once you adjust to them.
Klonopin is the most potent benzo ever invented.
Posted by Sad Panda on October 13, 2004, at 0:18:19
In reply to What is the most potent sedative/tranquilizer?, posted by mmcconathy on October 12, 2004, at 19:57:58
> I know there's lots of benzo's. And dont forget about the barbiturates.
>
> I am just curious, because i took Amytal 50mg, and it was pretty sedating.
>
> Thanks.....
>
> Matt
>Barbiturates work in pretty much the same way as Benzos except they depress the brain stem much more making their therapeutic index much smaller. The therapeutic index is the distance between a therapeutic dose & a lethal dose. One months worth of Benzos is unlikely to kill you if you take them all at once, but one weeks worth of Barbs can.
If Benzos don't give the anxiety relief you want, you could try the alternate path of 5-HT2A antagonists. 5-HT2A antagonism is the main feature that makes most antipsychotics anxiolytic. Antipsychotics use to be know as Major Tranquilizers, while Benzos use to be called Minor Tranquilizers. 5-HT2A antagonism is also a feature of TCA's such as Clomipramine, Amitriptyline, Nortriptyline and other drugs such as Remeron & Trazodone. 5-HT2A antagonism is probably the reason that Clomipramine & Amitriptyline are the most effective AD's. You don't need to take them in big doseages either. I take a low doseage of Amitryptyline as a sedative/anxiolytic/IBS treatment & continue to take Effexor as my AD.
Cheers,
Paul.
Posted by anxiety_free on October 13, 2004, at 4:09:09
In reply to What is the most potent sedative/tranquilizer?, posted by mmcconathy on October 12, 2004, at 19:57:58
Well...it depends on what you mean by "sedaating". Anti-anxiety drugs (benzos) are clean drugs targeted to kill off anxiety. The 2 most potent of those are xanax and klonopin. Barbiturates are rarely used these days, but my vote for the most sedating one would be Tuinal-seconal and amytal combined. Other than that, you might argue that old-school anti-psychotics are mega sedatives.
Posted by mmcconathy on October 13, 2004, at 11:26:53
In reply to sedatives, posted by anxiety_free on October 13, 2004, at 4:09:09
I researched, midazolam from the benzo's, will knock out an elephant.
And for the barbiturates, secobarbital, or Seconal would knock out a hippo.
But if anyone know anyelse, please post.
Just trying to be intresting...
Matt
Posted by utopizen on October 13, 2004, at 13:25:11
In reply to Re: midazolam, posted by mmcconathy on October 13, 2004, at 11:26:53
> Just trying to be intresting...
>
> MattBarbituates can kill you, and aren't as effective as benzos for anxiety. Mental illness isn't interesting, it's a serious medical problem you need to take seriously if you want to help yourself.
Posted by Jasmineneroli on October 13, 2004, at 18:25:49
In reply to Re: midazolam, posted by utopizen on October 13, 2004, at 13:25:11
I say this with the utmost respect, but I hope you are not "fishing" for info for a drug that might be "permanently" sedating at a certain dosage.
What is your reason for asking (beyond being "interesting")?? I think I might remember you as someone who has posted about being frustrated with meds/situation and expressing wishes to be free of it all...... I don't know if I'm mixing you up with someone else. I apologise if I am, but everyone here tries to be responsible and supportive. So if you do feel this way, talk to us. We're here to help. Talk to your doctor too.
Hope I haven't offended.
Jas
Posted by mmcconathy on October 14, 2004, at 11:33:52
In reply to Re: midazolam, posted by Jasmineneroli on October 13, 2004, at 18:25:49
oh my goodness, no way, im not in anyway on planning on trying seconal, no no i have experiemented before but its not serious, i know All the barbiturates i know can kill you, Marylin Monroe died from Nembutal, and Jemi Hendrix on something else.
No i took amytal (amobarbital), 50mg which is a low dose, to level out Dexedrine, xanax and klonopin gave me memory loss. I was just curious to know what the STRONGEST sedative is, just to know trivial knowlage.
Even if i did have a drug problem, i wouldnt tell my doctor! I would never want that on my record, and re-hab would be a nut house.
I have a strong will, and i dropped amytal faster as you can say drop.I hope this cleared up any misconceptions.....
Posted by Sad Panda on October 14, 2004, at 12:26:55
In reply to Re: midazolam, posted by mmcconathy on October 14, 2004, at 11:33:52
> oh my goodness, no way, im not in anyway on planning on trying seconal, no no i have experiemented before but its not serious, i know All the barbiturates i know can kill you, Marylin Monroe died from Nembutal, and Jemi Hendrix on something else.
>
> No i took amytal (amobarbital), 50mg which is a low dose, to level out Dexedrine, xanax and klonopin gave me memory loss. I was just curious to know what the STRONGEST sedative is, just to know trivial knowlage.
>
> Even if i did have a drug problem, i wouldnt tell my doctor! I would never want that on my record, and re-hab would be a nut house.
> I have a strong will, and i dropped amytal faster as you can say drop.
>
> I hope this cleared up any misconceptions.....
>
>If you are talking about mg for mg potency, then the winner would be Triazolam. Midazolam is a hospital only drug that is used pre-surgery, you would not use it daily because it is the benzo that erases memory the most. Thiopental use to be the barb used for general anesthetic & Propofol is the drug that is used these days for general anesthetic.
Cheers,
Paul.
Posted by J. Backer on October 14, 2004, at 12:37:59
In reply to Re: midazolam » mmcconathy, posted by Sad Panda on October 14, 2004, at 12:26:55
methaqualone,
Posted by mmcconathy on October 14, 2004, at 17:52:40
In reply to Re: midazolam, posted by J. Backer on October 14, 2004, at 12:37:59
Is it an effective sleeping med?
Benzo's are ok but i think ill start with something mild.
Is it stronger than Ambien?
Thanks
Posted by fallsfall on October 16, 2004, at 13:49:59
In reply to Re: i have a question about sonata, posted by mmcconathy on October 14, 2004, at 17:52:40
I've taken both. Sonata doesn't last as long as Ambien (4? hours instead of 8? hours). This is fine as long as your problem is *getting* to sleep, and once you are asleep you can stay asleep OK. If you are waking up at 3 or 4AM and wishing you could get back to sleep, Sonata isn't going to help you but Ambien might. Sonata works better if you can't be sure to have the 7 - 8 hours that Ambien will keep you asleep (of course, in that case, you should rearrange your schedule so you can get enough sleep...).
[I stopped taking Ambien because it make me spaz/jerk/twitch in my sleep]
This is the end of the thread.
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