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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Maxime on December 26, 2003, at 13:41:54
Hello. I know that people often take several SSRI's at the same time.
Does anyone know why you can't combine Nardil and Parnate? I am currently on Parnate. I wish I could add Nardil to help me with sleep etc. Why is combining the two dangerous?
Maxime
Posted by linkadge on December 26, 2003, at 14:59:29
In reply to Why can't MAOI's be combined?, posted by Maxime on December 26, 2003, at 13:41:54
I would think that they can; where'd you hear that they can't ??
Linkadge
Posted by Maxime on December 26, 2003, at 16:36:08
In reply to Re: Why can't MAOI's be combined?, posted by linkadge on December 26, 2003, at 14:59:29
Well come to think of it, I guess I haven't - LOL! There is just seems to be so much concern over switching from Nardil to Parnate and visa-versa without a washout period I assumed that it was dangerous to have the two in your system.
Maxime
> I would think that they can; where'd you hear that they can't ??
>
>
> Linkadge
Posted by SLS on December 26, 2003, at 16:44:21
In reply to Why can't MAOI's be combined?, posted by Maxime on December 26, 2003, at 13:41:54
> Hello. I know that people often take several SSRI's at the same time.
>
> Does anyone know why you can't combine Nardil and Parnate? I am currently on Parnate. I wish I could add Nardil to help me with sleep etc. Why is combining the two dangerous?
I don't know.Doctors that I have seen in the past whom were not at all shy about prescribing MAOIs would not mix them. I can see how adding one drug while already being on the other could be dangerous. Both drugs do things other than simply inhibit the MAO enzymes. When I was more responsive to the MAOIs, I would feel a "kick" within 30 minutes of dosing either Nardil or Parnate. Such an acute effect cannot be explained by MAO inhibition. Something else must be going on. My guess is that there is an increased release of catecholamines (NE and DA). This probably doesn't represent a problem with either drug when given alone because the inhibition of MAO occurs so gradually over time that the system accomodates to the more acute pharmacological effects. I would be interested to know if the same would be true if both drugs were begun simultaneously.
Over the last three years, I have only seen one person post here that they had combined Nardil with Parnate. They disappeared rather quickly afterwards. I would have liked to have asked him more questions. I hope he's still around.
- Scott
Posted by wsj on December 27, 2003, at 0:29:40
In reply to Why can't MAOI's be combined?, posted by Maxime on December 26, 2003, at 13:41:54
PARNATE (TRANYLCYPROMINE SULFATE) and NARDIL (PHENELZINE SULFATE)
Severity: MajorDescription: Treatment with both PHENELZINE and MONOAMINE OXIDASE INHIBITORS may result in dangerously high blood pressure, elevated body temperature, and headache.
Phenelzine is a medication that is called a monoamine oxidase inhibitor (MAO inhibitor). It may interact with other MAO inhibitors. Other MAO inhibitors include but are not limited to Marplan(R), Parnate(R), and Eldepryl(R). If you are not sure if your medication is a MAO inhibitor, contact your pharmacist or physician. Consult your physician before starting treatment with both phenelzine and another MAO inhibitor. Being treated with both phenelzine and another MAO inhibitor is not recommended. You should wait at least 10 days after you stop taking phenelzine before you start taking another MAO inhibitor. If you are already being treated with phenelzine and another MAO inhibitor, and are experiencing intense sweating, facial flushing, frequent headaches, or racing or pounding heart beat, contact your physician immediately.
...this is off drugstore.com but i have have never read anywhere that it would be ok to mix the two!
best to you!
wsj
Posted by Maxime on December 27, 2003, at 20:06:32
In reply to Re: Why can't MAOI's be combined? » Maxime, posted by wsj on December 27, 2003, at 0:29:40
Thanks. But I was thinking a low dosage of each maybe. I am on 90mg of Parnate right now. So I wonder what would happen on say 40 mg of Parnate and 30 of Nardil? Somehow I don't think I will find out. But I wish I could take Nardil in the afternoon so I could sleep at night!!! And I am scared to switch over to Nardil completly because of weight gain and I don't know if it is the depression buster that Parnate is for me. I don't suffer from any anxiety at all which is why my pdoc tried me on the Parnate first.
I am curious though.
Maxime
> PARNATE (TRANYLCYPROMINE SULFATE) and NARDIL (PHENELZINE SULFATE)
> Severity: Major
>
> Description: Treatment with both PHENELZINE and MONOAMINE OXIDASE INHIBITORS may result in dangerously high blood pressure, elevated body temperature, and headache.
> Phenelzine is a medication that is called a monoamine oxidase inhibitor (MAO inhibitor). It may interact with other MAO inhibitors. Other MAO inhibitors include but are not limited to Marplan(R), Parnate(R), and Eldepryl(R). If you are not sure if your medication is a MAO inhibitor, contact your pharmacist or physician. Consult your physician before starting treatment with both phenelzine and another MAO inhibitor. Being treated with both phenelzine and another MAO inhibitor is not recommended. You should wait at least 10 days after you stop taking phenelzine before you start taking another MAO inhibitor. If you are already being treated with phenelzine and another MAO inhibitor, and are experiencing intense sweating, facial flushing, frequent headaches, or racing or pounding heart beat, contact your physician immediately.
>
>
> ...this is off drugstore.com but i have have never read anywhere that it would be ok to mix the two!
>
>
> best to you!
> wsj
>
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