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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by michael on March 7, 2001, at 1:43:10
Hey Andrew,
I've been searching at PB, but haven't been able to find what I'm looking for... Did you not compile some info on mirapex, and results/effectiveness - as you had done w/amisulpride?
I'm trying to get a feel for the dosage range when used as an augmenter (specifically augmenting wellbutrin)... And also the time frame - I think I remember reading that it takes a week or so before positive effects were felt...?I may have even asked you these questions before...? or maybe just posted a question PB...? Either way, I couldn't find it...
Thanks for any help...
(btw, tried you at your old address first, and the msg didn't get through - just wondering, did I get something wrong, or is it just that you've moved?)Since I'm already writing - one more quick q for you... Any thoughgts on risperidone as an augmenter? Relative to Mirapex, or whatever...? (Looking at fatigue/energy/motivation & focus/concentration or mental agility/clarity/quickness...)
Or other thoughts/ideas (anyone?)? Unfortunately, amisulpride makes me feel worse over time - really run-down/exhausted... just my luck... (I've tried it a couple different times)
Anyway, so much for a quick question...
michael
Posted by AndrewB on March 7, 2001, at 2:30:39
In reply to Andrew, Q's re: mirapex..., posted by michael on March 7, 2001, at 1:43:10
Michael,
I haven't compiled a piece on Mirapex yet. Though I very may well when more responses come in. I am collecting all responses and the clinical trial info.
One should try to reach a dosage of approximately 5mg./day. This is divided into 3 doses a day. Start at 1/4 mg. per dose and titrate up slowly to minimize the nausea (which is normally transient).
Domperidone (from Farmacia Cerati) or Ondansetron (available here and overseas), both may be effective for nausea.
Risperdal of course is another antipsychotic with similarities and differnces in action to other antipsychotics like zyprexa, amisulpride and seroquel.
Given you iffy response to antipsychotics, Mirapex seems like a logical choice to trial next. Though an eventual trial with risperdal may be a pleasent surprise.
There is the possibility in my mind that many poor responders to amisulpride will be good responders to Mirapex. But only peoples’ responses will verify if this idea holds merit.
My impression is Mirapes doesn’t take a week to ‘kick in’ but, rather, it takes a week (or so) to get up to the effective dosage.
I don't know if the dosage of Mirapex is effected by combination with wellbutrin. Perhaps others have ideas on this but my impression is that as an add-on the Mirapex dosage is the same as if it were used as a stand-alone.
My email address is still andrewb@seanet.com. Sorry for not promptly responding to your recent email.
AndrewB
Posted by ChrisK on March 7, 2001, at 6:18:35
In reply to Re: Andrew, Q's re: mirapex..., posted by AndrewB on March 7, 2001, at 2:30:39
Michael, Andrew,
My own Mirapex response has been great. It's going on 2 1/2 months now and everything is still going strong. I noticed my response after about one week. It has done a lot to kill my anhedonia.
I take it in combo with Zyprexa which both my pdoc and I thought would a conflict but it hasn't conflicted at all. When I first started in Jan. I was also taking Wellbutrin. Since then the effects of Mirapex have allowed me to drop the WB while maintaining my main AD, Nortriptyline. I wouldn't call Mirapex exactly stimulating or activating but it has given me back my emotions. I can enjoy parts of life that had been a drag for a long time.
I'm actually looking forward to the spring and a return to the golf course. Maybe I'll even join a league this year. I've been playing in a dart league for the last month and find it very enjoyable. A year ago none of this would have been possible.
I'm not saying that Mirapex is the be-all and end-all but it has gotten me over that big hump. My pdoc had never tried it before and is now considering it for some of his harder to treat patients based on my response.
Andrew, If you are going to put together an analysis of Mirapex, search my name or e-mail me and I would be glad to help.
Chris
Posted by michael on March 7, 2001, at 10:53:46
In reply to Re: Andrew, Q's re: mirapex..., posted by AndrewB on March 7, 2001, at 2:30:39
Andrew,
As always, thanks for all the info.
Btw - no appologies necessary re: the e-mail that I mentioned... I must have keyed the address wrong - in any case it was returned to me, so it never got to you.
Thanks again - michael
> Michael,
>
> I haven't compiled a piece on Mirapex yet. Though I very may well when more responses come in. I am collecting all responses and the clinical trial info.
>
> One should try to reach a dosage of approximately 5mg./day. This is divided into 3 doses a day. Start at 1/4 mg. per dose and titrate up slowly to minimize the nausea (which is normally transient).
>
> Domperidone (from Farmacia Cerati) or Ondansetron (available here and overseas), both may be effective for nausea.
>
> Risperdal of course is another antipsychotic with similarities and differnces in action to other antipsychotics like zyprexa, amisulpride and seroquel.
>
> Given you iffy response to antipsychotics, Mirapex seems like a logical choice to trial next. Though an eventual trial with risperdal may be a pleasent surprise.
>
> There is the possibility in my mind that many poor responders to amisulpride will be good responders to Mirapex. But only peoples’ responses will verify if this idea holds merit.
>
> My impression is Mirapes doesn’t take a week to ‘kick in’ but, rather, it takes a week (or so) to get up to the effective dosage.
>
> I don't know if the dosage of Mirapex is effected by combination with wellbutrin. Perhaps others have ideas on this but my impression is that as an add-on the Mirapex dosage is the same as if it were used as a stand-alone.
>
> My email address is still andrewb@seanet.com. Sorry for not promptly responding to your recent email.
>
> AndrewB
Posted by AndrewB on March 8, 2001, at 6:01:40
In reply to Re: Andrew, Q's re: mirapex..., posted by ChrisK on March 7, 2001, at 6:18:35
Chris,
I like the idea of combining our efforts to put together an info. piece on Mirapex. I envision something that someone could give to their doctor so that they could be quickly brought up to speed on it.
Please email me (andrewb@seanet.com) and we can discuss composition and dividing the work load.
AndrewB
This is the end of the thread.
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