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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Dana G. on February 1, 2000, at 16:48:58
Has anyone taken Zyprexa? I took it and Depakote together and
gained a lot of weight in only about a 6 month period.
I have subsequently gotten on Seroquel, which is better,
but I still haven't lost any of the weight. The medicine
I take makes me too tired to exercise. I get tired too
easily. Is anyone on an anti-psychotic (besides resperidal)
that does not make you drowsy or gain weight?
Posted by JohnL on February 1, 2000, at 17:28:45
In reply to Antipsychotics and weight gain, posted by Dana G. on February 1, 2000, at 16:48:58
> Is anyone on an anti-psychotic (besides resperidal)
> that does not make you drowsy or gain weight?Amisulpride. Sadly it's not available in USA. But, no drowsiness, no weight gain. There are several overseas pharmacies who will mailorder it, but they do require a prescription from your doctor.
Posted by judy on February 1, 2000, at 19:21:57
In reply to Re: Antipsychotics and weight gain, posted by JohnL on February 1, 2000, at 17:28:45
JohnL,
Is that an atypical antipsychotic? Do you know what receptors it affects? Just curious. Thank you.
Posted by JohnL on February 2, 2000, at 3:19:01
In reply to Re: Antipsychotics and weight gain- JohnL, posted by judy on February 1, 2000, at 19:21:57
> JohnL,
> Is that an atypical antipsychotic? Do you know what receptors it affects? Just curious. Thank you.AndrewB knows a lot more about Amisulpride than I do. Hopefully he'll respond. But yes, it is an atypical antipsychotic. It is a presynaptic antagonist at low doses at the D2/D3 receptors, increasing dopamine transmission. It is effective at low doses for negative symptoms with fewer side effects than other antipsychotics, and effective at higher doses for positive symptoms. It's a shame the USA doesn't have this one.
Posted by ChrisK on February 2, 2000, at 5:46:19
In reply to Antipsychotics and weight gain, posted by Dana G. on February 1, 2000, at 16:48:58
I currently take Zyprexa and have suffered through the weight gain. My pdoc told me Pfizer is coming out with something called Zeldox. It is supposed to be similar to Zyprexa with fewer side effects. According to him it should be available in March.
Posted by Cass on February 5, 2000, at 14:19:05
In reply to Re: Antipsychotics and weight gain, posted by ChrisK on February 2, 2000, at 5:46:19
Do anti-psychotics increase the appetite, or do they have some other effect on hormones or metabolism? I recently started Risperdal. Now I'm wondering what to expect. I don't want the weight gain.
Posted by Noa on February 5, 2000, at 15:24:57
In reply to A question, posted by Cass on February 5, 2000, at 14:19:05
I don't know the answer, BUT, someone I know who was on Risperidone for a long while, did gain weight, but it SEEMED to be that she was CONSTANTLY thinking about food, felt hungry ALL the time, etc.
Posted by Cam W. on February 5, 2000, at 16:59:06
In reply to A question, posted by Cass on February 5, 2000, at 14:19:05
> Do anti-psychotics increase the appetite, or do they have some other effect on hormones or metabolism? I recently started Risperdal. Now I'm wondering what to expect. I don't want the weight gain.
Cass - The new antipsychotics all can cause weight gain to some extent. Risperdal is about in the middle. It is thought that they can cause a carbohydrate craving. Eating a balanced diet and snacking on veggies instead of junk food will help keep the weight gain to a minimum. Also, starting an exercise program will also help. With Risperdal there probably about a 4 - 5 lb gain in 8 months. Uusually after 8 months the weight stabilizes. Most of the old antipsychotics also caused weight gain as well, but they had so many other side effects that weigth gain was not an issue. The newer agents work so well that even those who do gain weight remain on the medication. Hope this helps. - Cam W.
Posted by Scott L. Schofield on February 7, 2000, at 9:47:03
In reply to Antipsychotics and weight gain, posted by Dana G. on February 1, 2000, at 16:48:58
> Has anyone taken Zyprexa? I took it and Depakote together and
> gained a lot of weight in only about a 6 month period.
> I have subsequently gotten on Seroquel, which is better,
> but I still haven't lost any of the weight. The medicine
> I take makes me too tired to exercise. I get tired too
> easily. Is anyone on an anti-psychotic (besides resperidal)
> that does not make you drowsy or gain weight?Zyprexa was a mother. I had an insatiable appetite and gained 5 pounds inside of a week.
- Scott
Posted by Dana G. on February 7, 2000, at 10:54:13
In reply to A question, posted by Cass on February 5, 2000, at 14:19:05
> Do anti-psychotics increase the appetite, or do they have some other effect on hormones or metabolism? I recently started Risperdal. Now I'm wondering what to expect. I don't want the weight gain.
I was told by my doctor that antipsychotics have a double effect:
they both increase your appetite and slow down your metabolism. There also
is alink to a hormone called leptin that in research has been shown a correlation
with obesity. I wasn't on Respirdal long enough,
but when I was on it, I was so sluggish I could
barely move--I just shuffled my feet. It is
inconceivable that anyone could not gain weight.
In my case with that antipsychotic, I was not more
hungry, but just less active.
This is the end of the thread.
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