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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by Diane on November 1, 1999, at 20:41:50
Organizing our diag./symptoms & med s-effects
Everyone writes down his/her diagnoses or symptoms & their experiences/reactions
to any and all drugs/chemicals and Posts it.
That way maybe we can find our TWIN here on the board (or a close 2nd) and go from
there. Learn from and share with our TWIN.Personally I NEED A STARTING POINT! A BASE of some kind. How about you?
Does that sound like a good/bad idea or have you oldtimers already done that?
Find a Psycho-Buddy :o)
Diane
Posted by JohnL on November 2, 1999, at 3:49:52
In reply to Organizing our diag./symptoms & med s-effects , posted by Diane on November 1, 1999, at 20:41:50
OK. I'm in. Hope this isn't too lengthy. I'll try to keep it simple and concise. I don't think reponses will help much in forming a base, because everyone is so different. But it will be interesting to see.
DIAGNOSIS: Double Depression. Dysthymia with overlapping severe depressive bouts. Possible bipolar.
PRIMARY SYMTOM: Anhedonia. Lack of pleasure, enjoyment in normal activities/hobbies. Other textbook depression symptoms too, but anhedonia is the big monster with me.
DRUG HISTORY:
All the SSRIs. Good for general depressive symptoms, but no benefit at all for anhedonia. Terrible sexual dysfunction with all except Prozac.
TCAs Notriptyline, Protriptyline. Couldn't handle the side effects to give a good trial. Protriptyline worsened tinnitus.
Wellbutrin. Super loud tinnitus. Like a jet plane in the ears. Couldn't give a fair trial. Fantastic sex.
Buspar. Same as Wellbutrin.
Serzone. Worsened depression. Worsened tinnitus. Worsened anhedonia. Excellent sex and sleep.
Effexor. Same as Serzone.
Moclobemide. Worsened depression. Unfair trial.
Lithium. Worsened tinnitus. Unfair trial.
Lamictal. Helpful on all symptoms except the anhedonia. No side effects.
St Johnswort. Same as Lamictal.
Remeron. Fairly helpful, but no effect on anhedonia. Great sleep.
Naltrexone. No effect. Neutral.
Herbs, gingko, ginseng. Mild energy boost, elevated physical endurance, but no mental benefits.CURRENTLY: Prozac+Remeron. Tapering off Lamictal. Tapering down St Johnswort. Keeping the Prozac because it is generally effective and is the only thing that actually quiets my tinnitus. But anhedonia remains fullblown.
BEST RESULTS SO FAR: Zoloft+Nortriptyline. Zoloft+Buspar. Sadly the Zoloft was just too unfriendly to sex. Buspar very loud tinnitus.
FUTURE: Augment Prozac with something else. Retry Nortriptyline, maybe try Desipramine with Prozac. Add a dompamine selective drug without tinnitus. Like Amisulpride, Pemoline, Bromocriptine.
SUMMARY: Anhedonia I believe is a distinct beast that can occur during depression or occur as a completely seperate monster. Since my other depressive symptoms are under control with Prozac, I am tempted to believe anhedonia is a seperate distinct condition more difficult to treat than depression. Whether it is a function of serotonin, NE, or dopamine is a mystery to me.
So, who out there sounds like me? Who's my Anhedonia Psycho-Buddy? :)
Posted by Carol on November 2, 1999, at 6:36:00
In reply to Re: Organizing our diag./symptoms & med s-effects , posted by JohnL on November 2, 1999, at 3:49:52
JohnL--Sorry about the previous post, dumb me hit "submit" instead of "delete"!
Anyway, think I might be your buddy...anhedonia to the max!(never knew it had a name, though). Even when the depression fades, I still seem to have no 'ability' to feel joy, happiness, or pleasure. Some of what should be the most joyous times of my life (wedding, birth of daughter) have been covered with fog of - something that won't let me FEEL joy. And on a day to day basis, no matter how well things are going in my life, I simply have none of the feeling of WELL-being that normal people get to experience.
Have also tried most of the same Meds. and 'Naturals'(St. Johns wort ect.) that you have...
TCA's made me worse, so tired I couldnot function and gained 15 pounds in 6 wks.
Prozac - nothing(at max dose)
Effexor- nothing(at max dose)
Both together - nothing (at max dose)Also, Zoloft, which helped my depression(slightly)for a while then stopped helping.
Have also been on Ritalin for fatigue - nothing(except when I took MUCH higher doses then recommended)
Currently, on Wellbutrin, but need longer trial to judge effectiveness.
Oddly, I have never suffered any 'physical' side effects(digestive, ect.)from anything, although with sexual function it's hard to tell, because the depression has often caused lack of interest there, so don't really know about Meds. effect on that.
Haven't tried any mood stabilizers because I have never experience a manic moment in my life(I wish!!).
Anyway, that's me in a nutshell(okay, a huge nutshell!) Sound familiar? Carol
Posted by Noa on November 2, 1999, at 8:23:39
In reply to Re: Organizing our diag./symptoms to JohnL OOOOPPS, posted by Carol on November 2, 1999, at 6:36:00
Diagnosis: Best bet=Double Depression.
Symptoms: "atypical"=fatigue, lack of energy, eating a lot, crying, sad, self-loathing, pessimistic outlook, hopelessness, anhedonia, lack of motivation, etc. etc. Also, anxiety, which seems to be the tradeoff for depression.
Treatments: many years of psychotherapy with much improvement, but recurrent bouts increased in frequency and intensity later on.
Also, medications:
Trazodone-about 6 months, not much effect
Prozac-two periods of time when I was on it for about one year, 20 mgs. Almost immediate improvement, within a week or two. Felt better, went off (the prevalent thinking of the time was you only needed to be on it for a while).
Prozac again-up to 30 mgs, about 16 months, discontinued because of tinnitus, rash, headaches.
Paxil-about 20 mgs about one year, pooped out. Increased dose, developed bad myoclonus, headaches. Lowered dose and added wellbutrin.
Paxil plus wellbutrin: developed bad diahrea. discontinued.
Effexor, about 150 mg, about six months.
Trazodone added to enable sleep.
Effexor-Begins to poop out, raise dose. Developed bad sweating, myoclonus, headaches. Lowered dose and added synthroid and cytomel. This worked for a while, then more poop out.
Effexor+synthroid+cytomel+Ritalin: good combo for a long time.
Get treatment for sleep apnea: severe fatigue goes away. Begin to feel better, but still dysthymic.
Switch to effexor XR=makes sleeping easier, fewer problems with forgeting dose, less myoclonus, sweating goes away. Increase to 225.
Serzone added in place of trazodone, when bad bout of depression happens. ALso-increase effexor to 375.As for the anhedonia: I wonder if this problem as you both describe it, is related to the problem I have: When I come out of the deeper depressions, I am highly anxious, and afraid to feel good, because it seems the good times don't last, and I will be whallopped by another killer depression just when I am letting down my guard. This is something I am focusing a lot on in therapy right now, how the major depressive episodes make the dysthymia so much more difficult because I am always on the alert for another episode. Having fun, feeling good, connecting to people terrify me because the loss of good feelings would be devastating if/when the next major depresion hits. So, pleasure=anxiety, which leads me to avoid pleasure.
Posted by Carol on November 2, 1999, at 11:42:41
In reply to Re: Name, Rank, and Serial Number, posted by Noa on November 2, 1999, at 8:23:39
> As for the anhedonia: I wonder if this problem as you both describe it, is related to the problem I have: When I come out of the deeper depressions, I am highly anxious, and afraid to feel good, because it seems the good times don't last, and I will be whallopped by another killer depression just when I am letting down my guard.
<<
Noa-- your case sounds very familiar to mine, except for your anhedonia. I'm never afraid to have good times, and always want to *feel* good. The way I have found to describe my problem, is that no matter how great my life is, no matter how happy I *should* be, my *brain* just does not seem to have any ABILITY to experience the *feeling* of happiness. There have been times when I have been intellectually 'glad' of certain things or happenings(during my merely dysthymic periods), but 'knowing' that something good has happened and actually 'feeling' the good of it, are two entirely different things. Comments, anyone? Carol
Posted by Sean on November 2, 1999, at 12:00:47
In reply to Organizing our diag./symptoms & med s-effects , posted by Diane on November 1, 1999, at 20:41:50
> Organizing our diag./symptoms & med s-effects
>
> Everyone writes down his/her diagnoses or symptoms & their experiences/reactions
> to any and all drugs/chemicals and Posts it.
> That way maybe we can find our TWIN here on the board (or a close 2nd) and go from
> there. Learn from and share with our TWIN.
>
> Personally I NEED A STARTING POINT! A BASE of some kind. How about you?
>
> Does that sound like a good/bad idea or have you oldtimers already done that?
>
> Find a Psycho-Buddy :o)
>
> Diane
Drug History:Amitriptyline : Worked great in combination with
lithium for many years. Weight
gain and heart problems.Zoloft : Caused insomnia, hypomania, difficulty
with orgasm. Also induced a form of
abstract anhedonia where I couldn't
make choices about what I wanted to do.
Everything was equal and boring.Prozac : Same.
Neurontin : Lethargy, increases depression, seems
to cause morning anxiety.Xanax : Take every now and then for anxiety and
insomnia.SAM-e : Starting now to see how it feels. The
research appears sound...
Posted by mat stone on November 2, 1999, at 13:39:15
In reply to Re: Organizing our diag./symptoms & med s-effects , posted by Sean on November 2, 1999, at 12:00:47
Diagnosis
= originally "atypical depression", since changed to "social phobia" which is much truer diagnosis. It is my opinion that social phobia is the cause of depression in my case. I wouldn't be surprised if a lot of people who get classified as "atypically depressed" have a similar root cause for their depression (what do you think?)Main symptons
= anxiety & lack of energyDrug History
Prozac (60mg) for 3 months
= no change whatsoeverEffexor (150mg->300mg) for 3 months
= muscle twitches & constipation, no other change :|Moclobemide (300mg) start this week
Have also had 7 sessions with a clinical psychologist which proved waste of time/money
ps. have only been recieving treatment for 6 months
mat
Posted by Racer on November 4, 1999, at 12:28:51
In reply to Re: Organizing our diag./symptoms & med s-effects , posted by mat stone on November 2, 1999, at 13:39:15
> Have also had 7 sessions with a clinical psychologist which proved waste of time/money
>
> ps. have only been recieving treatment for 6 months
>
> matYou might want to check again into psychologists. My experience has been that without both meds and talk, the symptoms may get better, but then they get worse again.
If that therapist didn't click for you, try another. I interviewed 14 of them when I was looking, paid for one appointment with each, then narrowed the field and went to a couple again, then made my decision. Especially for something like social phobia, it seems pretty intuitive that talking to someone about it would help a lot.
Good luck to you.
Posted by Diane on November 4, 1999, at 14:01:16
In reply to Organizing our diag./symptoms & med s-effects , posted by Diane on November 1, 1999, at 20:41:50
I'm just starting out on the journey to solve/correct my depression once and for all,
hopefully.
I promise I won't make a long post again.
This is my one time shot to find a similarly afflicted person.Self-Diagnosis: From what I've gathered so far, I seem to be a fluctuating mix
of/between major, atypical, dysthymic, plus chronic social phobia. But the overall
trend is always downward.Sleep: Some insomnia
Appetite: Never has it decreased
Worst time of day: Morning! (pre 1990 afternoon)
Energy: Diminished
Onset: Chronic
Age of onset: 11
Ability to function: Very impaired (no job)
Suicidal: Often
Mood reactive to
external events: Yes to negative events. No to positive.
Loss of interest: Yes, chronic, loosing hope, as well.Age 11.
That's when I first noticed:
I had no interest in school, friends, play etc.
I have been mostly alone from there on out.
I couldn't focus, concentrate, remember in school.
Consequently I came to fear school. Barely graduated HS
I've had no real close friends except Gene (whom I married).
I've never been sexually motivated. I've always been a wallflower, a non-entity.
I've always been a loner. A lonely loner. Not by choice.
I just can't connect with people. Especially now after all these years.I have always felt doubt, fear, insecure, worthless, hopeless, incapable, gutless
unmotivated. Always lacked drive, ambition, assertiveness.
I lack what ever IT is to succeed and be normal.
Thus over time lots of guilt & shame at being a dependent looser have stacked up.
I have always felt undeserving, inferior to all others, lost, helpless. Empty.
I've never been independent or self-supporting...I have no skills. Have never
worked, except that once (while on Methadone).
I've never even been physically alone except for 1 week in 1976.The last 10 years have added to the list anger, hate, frustration, negative aggression
endless negative thoughts, thoughts of suicide (I've decided that if I can't get back
on methadone or come up with some solution to my depression by the time Runty
dies (she is 8 yrs now) I will go get me a big old bag of heroin and die myself.)
I can't live like this anymore...34 years is enough! I'm 45 yrs old for christ sake.
A 45yr old baby. I want to live normal or die.I hate my parents, I always have. They've always been a negative intrusion.
(" You can't do that Diane because....")
Having to live with them again is exacerbating my problem! I'd have gotten back on
Methadone 4 yrs ago if it wasn't for them. They are against all drugs (except of
course the ones they are dependent on). If they knew I was considering ADs
they'd make me feel so bad about it (like a freak) that no amount of AD
would work...would override their negative garbage, looks of disgust. Which is one
of
the reasons I'm going thru my GP and not a Psychiatrist.
I have never been able to fight off, sluff off their negative garbage.
They bombard me with it. Even when I lived 800miles away. They phoned endlessly.They use shame & guilt to get what they want. Are OVERPROTECTIVE.
Being totally dependent on them is killing me and is giving them even more
license to intrude. Talking to them is like talking to a wall.
This is one of the worst positions I've ever been in.
I'm trapped like a bloody rat. If I had balls they'd have em!
I'm getting more and more desperate and am barely holding on right now.All the above feelings still apply today. The past dominates because there is no
future. I think about past events every morning. Sometimes all day. I hate the past, I
want/need to BLOCK IT OUT . It cripples me with anger. I can't go forward
because it's always standing in my way.I find all the different AD meds confusing. Am looking into books now.
I hope the above and below will aid in finding the best one(s) for me.
If someone here can apply this page to themselves then maybe I can follow their
lead or we can hasten the AD trials by each trying different drugs until one work.Drugs that I've experienced & my reactions:
Zoloft™ gave me headaches.
Prozac™ I turned violent after only 9hrs in my system. I grabbed my mom by the
throat. Didn't think nothing of it. No restraint.
Xanax made me dopey, useless. Withdrawal seizures. Word difficulties yrs after
Mellaril, I can't remember. It wasn't impressed tho obviously.
Klonopin made me dopey, useless.
Vallium, nothing.
Tryptophan, the amino acid, gives me nightmares.
Alcohol, one drink and I've got a headache.
Caffeine, angry, nervous, negative grrrrrrr
Pot, depressed, insecure & self-conscious in the extreme! Nervous. Can't breathe.
Cocaine, too euphoric. Crash is unbelievably depressing. Can't breathe.
Speed (street) max. depression, scattered, can't stand it, easily winded.
Demerol®, nothing.
Codeine, no big deal. Killer on the stomach
Vicodin, feels similar to methadone/heroin for a very little while. Kills the stomach
Morphine is too dopey. A little too much and you're out like a light.
Heroin is much better but it's an occupation. The returns are no longer worth the
effort.
Methadone is perfect. Long acting. It stabilizes. There is no debilitating rush or crash.It's a constant even flow. The only drug that has worked.
!Methadone stimulates my body and my mind! "Type A in a type B body" I became
just the opposite of myself. A Miracle. Darkness turned to light.
I'm not going to elaborate because I'd fill up many pages easily.
Suffice it to say there ain't nothing I desire more....
..........................outside of Gene alive and Runty to live forever.So there's my diag./symptoms & med s-effects... condensed.
I need to forget... what I am :o)AGAIN I apologize for the length and/or possible uselessness of information.
Posted by Racer on November 4, 1999, at 17:08:55
In reply to Re: my diag./symptoms & med s-effects , posted by Diane on November 4, 1999, at 14:01:16
I'm not your psycho buddy, but I am touched by what you're going through. How awful, and to be so isolated when you need someone to offer support! You poor thing.
I'm glad you're talking to your doctor about this, and hope that you find something that helps you get through this and come out stronger. My guess is that if we did a poll on the board, it would turn out that most of us started having trouble when we were about 11, seems like that's a dangerous age. I know that's about when I started...
As far as ADs go, I am loving Effexor XR, though I know some people don't tolerate it well. It seems to work on a mix of neurotransmitters, while a lot of the others you've mentioned work on only one. Your doctor should be able to recommend something that will help you, and I send you my strongest feelings and hopes for you to find some relief. There's nothing worse than that trapped feeling. Believe me, I know about that one, the walls of life closing in.
As for diagnosis, I'm not sure it helps much, beyond being a label that helps the doctors choose drugs to try. My best ever girlfriend once told me that her 'official' diagnosis by her psychiatrist was that she was 'Looney Tunes', and that made sense to me. Personally, I'm not crazy, just nuts, you know?
Good luck and keep us posted.
Posted by Carol on November 5, 1999, at 13:02:31
In reply to Diane!, posted by Racer on November 4, 1999, at 17:08:55
Diane,
My case is similar to yours,but not near as severe. I do feel for you regarding having to live with your parents. I was once in the situation of almost having to go live with mine, and I knew that if it really came down to that, I would kill myself before I would do it. So, I know where you are coming from. Don't give up the idea of getting some kind of therapy, try to find a way to do it without your parents finding out. Maybe your GP could help you find someone, then you could just say that there is something wrong and your Doctor recommended a "specialist". Then just call your sessions, "Dr's" appointments(As you see, I have become an expert at protecting my psychological privacy from my folks, who only cause me more angst if they knew the truth). Anyway, medicine alone probably will not be enough to get you where you want to be. I know. I finally had to break down and get the therapy myself, in order to get some *peace* from my past.
As for the Effexor, it did not help me, *but* my new doctor blamed the fact that I was never put on a high enough dosage. Like you, a lot of my problem is fatigue and lack of motivation. My new psyciatrist explained that in order to get an "activating" effect, Effexor needs to be taken at very high doses(above the 'standard' maximum of 225 mgs.). He said that the medicine actually changes effects at high doses and acts more like Wellbutrin and other "energizing" anti-depressants. Anyway, you may need an actual Psychiatrist to get such a high dose prescription.
Hope this helps.
Carol
Posted by Janice on November 7, 1999, at 20:18:17
In reply to Re: my diag./symptoms & med s-effects , posted by Diane on November 4, 1999, at 14:01:16
you need to get yourself some more methadone. There must be some way to do this? Sorry to hear about your parents; they sound truly dreadful. And they probably think they are giving you 'support'.
Janice.
Posted by Jon on November 28, 2000, at 9:33:45
In reply to Re: Organizing our diag./symptoms & med s-effects , posted by JohnL on November 2, 1999, at 3:49:52
Hello John,
>
> PRIMARY SYMTOM: Anhedonia. Lack of pleasure,
>
> DRUG HISTORY:
> All the SSRIs. Good for general depressive > TCAs Notriptyline, Protriptyline. Couldn't > Lithium. Worsened tinnitus. Unfair trial.
> Lamictal. Helpful on all symptoms except the > Naltrexone. No effect. Neutral.
> Herbs, gingko, ginseng. Mild energy boost,OK, you may not be reading this thread anymore as you posted your message one-year ago, but I suggest you may have a problem with your opioid receptor system. I don't think 5-HT or NA would play a major role in anhedonia, the best candidates being either DA or opioids.
The rewarding properties of hedonic drugs like cocaine and heroin stimulate the DA and opioid systems respectively. Unfortunately im not aware of any medications that can re-balance these systems without creating physical dependency, which you really don't want. However, if you have ever had any experience with either of these classes of drugs can you please let me know as I'm researching anhedonia at the moment.
My email is jon_walker@popmail.com (in case this list auto-deletes email addresses: jon_walker at popmail dot com).
Do small amount of codeine help?
Hope you're doing OK.
Jon.
>
> SUMMARY: Anhedonia I believe is a distinct beast that can occur during depression or occur as a completely seperate monster.
Posted by JohnL on November 29, 2000, at 3:51:22
In reply to Re: Organizing our diag./symptoms med s-effects , posted by Jon on November 28, 2000, at 9:33:45
Hi,
Wow, I had forgotten about that old post. Since then, a million miles and a million drugs later, I have found some things that work well on my anhedonia.I think you are right that opioid systems could be involved in anhedonia. And there doesn't appear to be any non-addictive way to treat that. But it seems many psychiatric drugs may have indirect actions on opioid systemes, through domino chain reactions.
In general though I've come to believe anhedonia is primarily a dysfunction of the noradrenaline and dopamine systems. Basically what I've gathered indicates that NE is related to drive, while DA is related to pleasure, both of which added together make up components of anhedonia.
I found Adrafinil fairly effective. That would indicate that my alpha-1 receptors are blocked, clogged, or somehow dsyfunctional. NE levels are fine, but the related receptors are not. Merely increasing NE levels does nothing to fix the problem.
Amisulpride also is fairly effective. That would indicate that dopamine is somehow dsyfunctional.
But the best of all is when these two drugs are combined. The sum is greater than the two parts added together. To further complicate the picture, a tiny dose of Prozac in the background further enhances their effects. Obviously the chemistry is complicated, but it has become clear that NE and DA are primary systems in my anhedonia.
It is also surprising to me that it takes a very specific drug to correct the problem. Just any DA or NE drug won't do. For example, Amisulpride stimulates DA. But so do Ritalin and Adderall. But neither Ritalin or Adderall affected my anhedonia, while Amisulpride did. And most NE enhancing drugs actually made me more depressed. Yet by stimulating NE receptors with Adrafinil, rather than increasing NE levels, I felt much better. Go figure.
After all is said and done, the moral of the story is the same as it always has been. That is, we just have to try different things until one works. If one drug in a particular class doesn't work, another might. But generally I've come to believe that if anhedonia is a primary symtom (as in some depressions and some schizophrenics), then focusing on different ways to influence NE and DA is probably the quickest way to find relief. Drugs of varying mechanisms should be tried.
John
Posted by michael on November 29, 2000, at 22:38:12
In reply to Anhedonia Jon, posted by JohnL on November 29, 2000, at 3:51:22
John,
Just wondering if you've ever tried ephedrine, and what your experience might've been?
I've got a similar profile, did't find reboxetine helpful, made me edgy/feel a bit ill. However find ephedrine helpful & much less/barley/almost not edgy/wired.
Just curious. Trying adding amisulpride again to adrafinil. Think it might be working for me - roughly a week with the two. Also starting 10mg selegiline... I know I should only change one variable at a time, but I figured the selegiline'll take a while to have an effect...? (rationalizing...)
Anyway, glad to hear things are going better. Btw, any experience w/bromocriptine?
michael
> Hi,
> Wow, I had forgotten about that old post. Since then, a million miles and a million drugs later, I have found some things that work well on my anhedonia.
>
> I think you are right that opioid systems could be involved in anhedonia. And there doesn't appear to be any non-addictive way to treat that. But it seems many psychiatric drugs may have indirect actions on opioid systemes, through domino chain reactions.
>
> In general though I've come to believe anhedonia is primarily a dysfunction of the noradrenaline and dopamine systems. Basically what I've gathered indicates that NE is related to drive, while DA is related to pleasure, both of which added together make up components of anhedonia.
>
> I found Adrafinil fairly effective. That would indicate that my alpha-1 receptors are blocked, clogged, or somehow dsyfunctional. NE levels are fine, but the related receptors are not. Merely increasing NE levels does nothing to fix the problem.
>
> Amisulpride also is fairly effective. That would indicate that dopamine is somehow dsyfunctional.
>
> But the best of all is when these two drugs are combined. The sum is greater than the two parts added together. To further complicate the picture, a tiny dose of Prozac in the background further enhances their effects. Obviously the chemistry is complicated, but it has become clear that NE and DA are primary systems in my anhedonia.
>
> It is also surprising to me that it takes a very specific drug to correct the problem. Just any DA or NE drug won't do. For example, Amisulpride stimulates DA. But so do Ritalin and Adderall. But neither Ritalin or Adderall affected my anhedonia, while Amisulpride did. And most NE enhancing drugs actually made me more depressed. Yet by stimulating NE receptors with Adrafinil, rather than increasing NE levels, I felt much better. Go figure.
>
> After all is said and done, the moral of the story is the same as it always has been. That is, we just have to try different things until one works. If one drug in a particular class doesn't work, another might. But generally I've come to believe that if anhedonia is a primary symtom (as in some depressions and some schizophrenics), then focusing on different ways to influence NE and DA is probably the quickest way to find relief. Drugs of varying mechanisms should be tried.
> John
Posted by JohnL on November 30, 2000, at 3:58:31
In reply to Re: Anhedonia Jon » JohnL, posted by michael on November 29, 2000, at 22:38:12
Hi Michael,
Yes, I have tried ephedrine. It made me a little edgy, but a definite improvement of drive and mood. I only took it one time out of curiousity. But it definitely became clear to me at that time that my depression probably had little to do with serotonin chemistry.I got worse real fast on Reboxetine.
I take Selegiline usually once every two days or so. Very small dose though. I break the pill into about 1mg chunks. I have discovered that 5mg or 10mg daily actually starts making me feel a little worse and also impotent. With Selegiline, a little bit can go a long way.
I've tried low dose Bromocriptine. It made me tired and depressed. I guess high doses supposedly do the opposite, but the side effect of nausea makes it hard to attempt that. I just said forget it. I know in literature, on the web, and at antiaging websites there is a lot of hype about Selegiline, Dilantin, and Bromocriptine. But in my experience most of it is just that...hype. Adrafanil and Amisulpride are the unsung heroes as I see it.
John
This is the end of the thread.
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